Original article
Comparison of cord blood immunoglobulin E concentrations and maternal allergy for the prediction of atopic diseases in infancy

https://doi.org/10.1016/0091-6749(80)90234-1Get rights and content

Abstract

Total serum IgE levels were determined in 136 newborns and their mothers and in 54 of their fathers, using the paper radioimmunosorbent test (PRIST) technique. IgE specific antibodies for house dust (Dermatophagoides pteronyssinus), orchard grass, timothy grass, and cow's milk were measured with the radioallergosorbent test (RAST). One hundred thirty-three RAST assays were negative in newborns, and in three cases RAST for cow's milk was positive. Cord blood IgE ranged from 0 to 5.5 IU/ml (mean 0.32 ± 0.54 IU/ml); levels were significantly (p < 0.05) higher when maternal IgE was over 100 IU/ml and when mothers had received progesterone therapy during the pregnancy. Salbutamol administration or tobacco smoking during pregnancy did not influence newborn IgE. A clinical follow-up study was conducted in 83 infants for 9 mo. Nine infants developed definite atopic disease, and possible allergic diseases were noted in eight other infants. The IgE level at birth appeared to be more predictive for the development of allergy in infancy than the family history.

References (33)

  • RN Hamburger et al.

    Development of IgE and allergy during the first year of life: Preliminary data

    J Allergy Clin Immunol

    (1973)
  • HG Rapaport et al.

    Incidence of allergy in a pediatric population: Pilot survey of 2,169 children

    Ann Allergy

    (1960)
  • NIM Kjellman

    Predictive value of high IgE levels in children

    Acta Paediatr Scand

    (1976)
  • PP Van Arsdel et al.

    Frequency and hereditability of asthma and allergic rhinitis in college students

    Acta Genet Stat Med

    (1959)
  • SGO Johansson et al.

    Comparison of IgE values as determined with different solid phase radioimmunoassay methods

    Clin Allergy

    (1976)
  • L Nye et al.

    A detailed investigation of circulating IgE levels in a normal population

    Clin Allergy

    (1975)
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