Cardiovascular and analgesic effects of a highly palatable diet in spontaneously hypertensive and Wistar-Kyoto rats
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High fat diet aggravates atrial and ventricular remodeling of hypertensive heart disease in aging rats
2018, Journal of the Formosan Medical AssociationCitation Excerpt :This study used ad libitum-fed rats, therefore the results in biochemical analysis may vary according to the calories that they actually consumed. Another reason for lower plasma cholesterol in SHR is the difference of metabolic pathway between SHR and WKY, which had been suggested by Zhang, et al..25 The possibility exists that this inherited metabolic difference may attribute to different impact of HFD on cardiac remodeling in aging WKY and SHR in this study.
Ketoprofen and antinociception in hypo-oestrogenic Wistar rats fed on a high sucrose diet
2016, European Journal of PharmacologyCitation Excerpt :Controversies exist regarding the perception of pain in obese subjects. Some studies report a hyperalgesic state associated with obesity (Roane and Martin, 1990; Sugimoto et al., 2008; Buchenauer et al., 2009), while others have proposed the existence of hypoalgesic processes (Ramzan et al., 1993; Zhang et al., 1994; Sugimoto et al., 2008). Moreover, the most frequent cases that have been documented clinically in obese people involve back pain (Hitt et al., 2007; D’Arcy, 2011) and arthritis pain (Marcus, 2004), triggered mainly due to a mechanical effect on the joints by weight gain.
Effects of diet-induced obesity on motivation and pain behavior in an operant assay
2013, NeuroscienceCitation Excerpt :Previous studies assessing thermal or mechanical nociception in rodent models of obesity have been limited to the hindpaw or tail in a variety of obesity models. In many cases, thermal insensitivity in the hindpaw has been attributed to advanced diabetic neuropathy that can be concomitant with obesity (Zhang et al., 1994; Vareniuk et al., 2007; Sugimoto et al., 2008; Davidson et al., 2009). Our findings suggest that, unlike nerves in the extremities, the trigeminal system does not seem to be affected by diabetic neuropathy.
Diet-induced obesity alters behavior as well as serum levels of corticosterone in F344 rats
2009, Physiology and BehaviorCitation Excerpt :A possible association between the parameter rearing and the aggressive behavior of DIO rats has to be further investigated in future studies. Our findings in the hotplate test point to a lower pain threshold in obese rats, while previous studies in different obese rat strains reported controversial results for the tail-flick test [32,33]. This may be due to the different employed tests in the preceding studies.