Elsevier

Life Sciences

Volume 57, Issue 19, 29 September 1995, Pages 1717-1735
Life Sciences

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In vivo effects of superantigens☆

https://doi.org/10.1016/0024-3205(95)02045-KGet rights and content

Abstract

Superantigens are potent immunostimulatory molecules that activate both T cells and antigen presenting cells. The consequences of superantigen exposure range from induction of T cell proliferation, massive cytokine release and systemic shock to immunosuppression and tolerance. Superantigens have been directly implicated in a number of human conditions including food poisoning and toxic shock. In addition, there is evidence to suggest that superantigens are involved in the initiation of autoimmunity, and the immune dysfunction associated with HIV infection. Because of their possible role in human disease, and their potential use in immune therapy, it is important that we more completely understand the in vivo effects of superantigens.

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    ☆

    This work was supported by National Institutes of Health grants AI31489 (M.A.B.) CA56570 and AI31596 (D.L.W.), P30 CA21765 (CORE grant) and the American Lebanese Syrian Associated Charities (ALSAC).

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