Research articleOn the role of human herpesvirus 6 in viral latency in nervous tissue and in cerebral lymphoma
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Primary Central Nervous System Lymphoma
2012, Brain TumorsPrimary central nervous system lymphoma
2011, Brain Tumors: An Encyclopedic Approach, Expert Consult - Online and PrintDetection of human herpesvirus-6 variants in pediatric brain tumors: Association of viral antigen in low grade gliomas
2009, Journal of Clinical VirologyCitation Excerpt :Among higher grade gliomas (WHO grades 3–4), there was a tendency for HHV-6A/B gp116/64/54 positive patients to have a shorter survival; however, this did not reach statistical significance (P = 0.094) (Fig. 3D). Our results are consistent with prior studies demonstrating HHV-6 by PCR in both non-tumor (32–67%) and malignant (8.2–37%) adult brain tissue.11,12,23,24 Recently, Neves et al. reported no detectable HHV-6 DNA by real time PCR in 35 low grade astrocytomas,25 compared to our finding of 44–72% positive by nested PCR, ISH, or IHC.
Neuropathology of Viral Infections of the Central Nervous System
2008, Neuroimaging Clinics of North AmericaCitation Excerpt :The virus also infects monocytes, bone marrow progenitor cells and can be found in umbilical cord blood [18]. Latent infection can be found on monocytes and cells in CNS [19,20]. These viral infections are important cause of febrile seizures and may lead to cerebral atrophy [21,22].
Human herpesvirus 6 and malignancy: A review
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2012, Hematologic Cancers: From Molecular Pathobiology to Targeted Therapeutics