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Comparison of albumin versus bicarbonate treatment for neonatal metabolic acidosis

  • NEONATOLOGY
  • Published:
European Journal of Pediatrics Aims and scope Submit manuscript

Abstract

In this study the effectiveness of 4.5% human albumin was compared with 4.2% sodium bicarbonate for neonatal metabolic acidosis, using a randomised controlled trial. The change in median pH following bicarbonate was more than twice that in the albumin group. This was statistically significant.

Conclusion In normotensive infants, use of bicarbonate to correct metabolic acidosis may be more effective than use of albumin.

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Authors and Affiliations

  1. Neonatal Unit, City Hospital, Nottingham NG5 1PB, UK, , , , , , GB

    H. Dixon

  2. Manchester Children's Hospitals' NHS Trust, Royal Manchester Children's Hospital, Hospital Road, Pendlebury, Manchester M27 4HA, UK, , , , , , GB

    K. Hawkins

  3. Academic Division of Child Health, School of Human Development, University Hospital, Queen's Medical Centre, Nottingham NG7 2UH, UK, e-mail: Terence.Stephenson@nottingham.ac.uk, Tel.: +44-115-9709255, Fax: +44-115-9709382, , , , , , GB

    T. Stephenson

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  1. H. Dixon
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  2. K. Hawkins
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  3. T. Stephenson
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Received: 5 March 1998 / Accepted in revised form: 7 July 1998

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Dixon, H., Hawkins, K. & Stephenson, T. Comparison of albumin versus bicarbonate treatment for neonatal metabolic acidosis. Eur J Pediatr 158, 414–415 (1999). https://doi.org/10.1007/s004310051104

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  • DOI: https://doi.org/10.1007/s004310051104

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