Abstract
A study was conducted to determine if a two-dose regimen of influenza vaccine would enhance the immunologic response of 41 patients with lymphoma receiving chemotherapy. Hemagglutinin-inhibiting antibody responses to influenza A/H1N1, A/H3N2 and B virus occurred in 32 %, 24 % and 20 % of patients following one dose, and in 49 %, 41 % and 46 % of patients following two doses, respectively. Responses to one or more vaccine components occurred in 42 % of patients after one dose and in 71 % after two doses. Fifty percent of the patients who did not respond after one dose responded after two doses. A two-dose regimen of influenza immunization may significantly enhance the response rate of cancer patients receiving chemotherapy.
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Couch RB, Kasel JA, Glezen WP, Cate TR, Six HR, Taber LH, Frank AL, Greenberg SB, Zahradnik JM, Keitel WA: Influenza: its control in persons and populations. Journal of Infectious Diseases 1986, 153: 431–440.
Centers for Disease Control: Prevention and control of influenza. I: Vaccines: recommendations of the Advisory Committee on Immunization Practices. Morbidity and Mortality Weekly Report 1993, 421: 1–14.
Borella L, Webster RG: The immunosuppressive effects of long-term combination chemotherapy in children with acute leukemia in remission. Cancer Research 1971, 31: 420–426.
Sybesma J, Holtzer JD, Borst-Eilers E, Moes M, Zegers B: Antibody response in Hodgkin's disease and other lymphomas related to HL-A antigens, immunoglobulin levels and therapy. Vox Sanguinis 1973, 25: 254–262.
Feery BJ, Sullivan JR, Hurley TH, Evered MG: Immunization with influenza vaccine in patients with haematological malignant disease. Medical Journal of Australia 1977, 1: 292–294.
Ortbals DW, Liebhaber H, Presant CA, Van Amburg AL, Lee JY: Influenza immunization of adult patients with malignant diseases. Annals of Internal Medicine 1977, 87: 552–557.
Ganz PA, Shanley JD, Cherry JD: Responses of patients with neoplastic diseases to influenza virus vaccine. Cancer 1978, 42: 2244–2247.
Stiver GH, Weinerman BH: Impaired serum antibody response to inactivated influenza A and B vaccine in cancer patients. Canadian Medical Association Journal 1978, 119: 733–738.
Schafer AI, Churchill WH, Ames P, Weinstein L: The influence of chemotherapy on response of patients with hematological malignancies to influenza vaccine. Cancer 1979, 43: 25–30.
Steinherz PG, Brown AE, Gross PA, Braun D, Ghavimi F, Wollner N, Rosen G, Armstrong D, Miller DR: Influenza immunization of children with neoplastic diseases. Cancer 1980, 45: 750–756.
Gross PA, Gould AL, Brown AE: Effect of cancer chemotherapy on the immune response to influenza virus vaccine: review of published studies. Reviews of Infectious Diseases 1985, 7: 613–618.
Gross PA: Reactogenicity and immunogenicity of bivalent influenza vaccine in one- and two-dose trials in children: a summary. Journal of Infectious Diseases 1977, 136, Supplement: 616–625.
Mancini G, Arangio-Ruiz G, Bianchi B, Diana L, Maccia T, Donatelli I, Castrucci MR, Campitelli L, Ruggieri A: Influenza vaccination in elderly residents in nursing homes: immune response to trivalent and monovalent inactivated influenza virus vaccine in the season 1986–87. European Journal of Epidemiology 1989, 5: 214–218.
MacKenzie JS: Influenza subunit vaccine: antibody responses to one and two doses of vaccine and length of response, with particular reference to the elderly. British Medical Journal 1977, 1: 200–202.
Palmer DF, Coleman MT, Dowdle WR, Schild GC: Advanced laboratory techniques for influenza diagnosis. Center for Disease Control, Atlanta, 1975.
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Lo, W., Whimbey, E., Elting, L. et al. Antibody response to a two-dose influenza vaccine regimen in adult lymphoma patients on chemotherapy. Eur. J. Clin. Microbiol. Infect. Dis. 12, 778–782 (1993). https://doi.org/10.1007/BF02098469
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DOI: https://doi.org/10.1007/BF02098469