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Oral bacteriotherapy for viral gastroenteritis

  • Intestinal Disorders, Inflammatory Bowel Disease, Immunology, And Microbiology
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Abstract

The effect of orally administered lactobacilli on acute rotavirus diarrhea was tested in 42 well-nourished children ages 5–28 months. After oral rehydration, the patients were randomized to a study group, receiving humanLactobacillus casei strain GG 1010 colony-forming units twice daily for five days, or a control group not given lactobacilli.Lactobacillus GG was found in the feces in 83% of the study group. The diarrheal phase was shortened in that group. Dietary supplementation with lactobacilli significantly influenced the bacterial enzyme profile: urease activity during diarrhea transiently increased in the control group but not in the study group;F=8.6,P=0.01. No intergroup differences were found in β-glucuronidase, β-glucosidase, and glycocholic acid hydrolase levels. We suggest that rotavirus infection gives rise to biphasic diarrhea, the first phase being an osmotic diarrhea and the second associated with overgrowth of specifically urease-producing bacteria. Oral bacteriotherapy appears a promising means to counteract the disturbed microbial balance.

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Authors and Affiliations

  1. Department of Clinical Nutrition, University of Kuopio, Finland

    Erika Isolauri MD, Minna Kaila MD, Hannu Mykkänen PhD, Wen Hua Ling PhD & Seppo Salminen PhD

  2. Department of Physiology, University of Kuopio, Finland

    Erika Isolauri MD, Minna Kaila MD, Hannu Mykkänen PhD, Wen Hua Ling PhD & Seppo Salminen PhD

  3. Department of Biochemistry and Food Chemistry, University of Turku, Finland

    Erika Isolauri MD, Minna Kaila MD, Hannu Mykkänen PhD, Wen Hua Ling PhD & Seppo Salminen PhD

  4. Department of Clinical Medicine, University of Tampere, P.O. Box 607, 33101, Tampere, Finland

    Erika Isolauri MD, Minna Kaila MD, Hannu Mykkänen PhD, Wen Hua Ling PhD & Seppo Salminen PhD

Authors
  1. Erika Isolauri MD
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  2. Minna Kaila MD
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  3. Hannu Mykkänen PhD
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  4. Wen Hua Ling PhD
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  5. Seppo Salminen PhD
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Additional information

This study was supported by the Academy of Finland and the Foundation for Nutrition Research (Finland).

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Isolauri, E., Kaila, M., Mykkänen, H. et al. Oral bacteriotherapy for viral gastroenteritis. Digest Dis Sci 39, 2595–2600 (1994). https://doi.org/10.1007/BF02087695

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  • DOI: https://doi.org/10.1007/BF02087695

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