Abstract
In an attempt to stimulate bone resportion, a 10-week-old infant with malignant infantile osteopetrosis was treated with high doses of calcitriol, a potent bone resorption stimulatory agent, combined with a low calcium diet to prevent hypercalcaemia. Although calcitriol administration was initiated at this very young age, our patient did not show any clinical, radiological, or histological improvement. Despite reports of positive results of this treatment in the literature, our patient did not reveal any signs of bone resorption. She eventually died from the complications of osteopetrosis at the age of 6 months after 88 days of therapy.
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Bergman J, Loxley R (1963) Two improved and simplified methods for the spectrophotometric determination of hydroxyproline. Anal Chem 35:1961–1965
Coccia PF, Krivit W, Cervenka J, Clawson C, Kersey JH, Kim TH, Nesbit ME, Ramsay NKC, Warkentin PI, Teitelbaum SL, Kahn AJ, Brown DM (1980) Successsful bone-marrow transplantation for infantile malignant osteopetrosis. N Engl J Med 302:701–708
Frölich M, Dijk-Besling M van, Sokolowski G, Nieuwenhuijzen Kruseman AC (1982) Comparison of two radioimmuno assays used for the detection of early stages of medullary carcinoma of the thyroid. J Endocrinol 94 (S25):13
Glorieux FH, Pettifor JM, Marie PJ, Delvin EE, Travers R, Shepard N (1981) Induction of bone resorption by parathyroid hormone in congenital malignant osteopetrosis. Metab Bone Dis 3:143–150
Helfrich MH, Aronson DC, Everts V, Mieremet RHP, Gerritsen EJA, Eckhardt PG, Groot CG, Scherft JP (1988) Morphologic features of bone in human osteopetrosis and pycnodysostosis. In: Helfrich MH. Morphology and in vitro formation of normal versus osteopetrotic osteoclasts in microphtalmic mice and in humans. Doctorate Thesis, University of Leiden. Kanters, Alblasserdam, pp 101–27
Hoogenboezem T, Degenhart HJ, Muinck Keizer-Schrama SMPF de, Bouillon R, Grose WFA, Hackeng WHL, Visser HKA (1989) Vitamin D metabolism in breast-fed infants and their mothers Pediatr Res 25:623–628
Key L, Carnes D, Cole S, Holtrop M, Bar-Shavit Z, Shapiro F, Arceci R, Steinberg J, Gundberg C, Kahn A, Teitelbaum S, Anast C (1984) Treatment of congenital osteopetrosis with high-dose calcitriol. N Engl J Med 310:409–415
Marks SC (1984) Congenital osteopetrotic mutations as probes of the origin, structure and function of osteoclasts. Clin Orthop 189:239–263
Prockop DJ, Udenfried A (1960) A specific method for the analysis of hydroxyproline in tissues and urine. Anal Biochem 1:228–229
Rouleau MF, Warshawsky H, Marks SC, Goltzman O (1986) Calcitonin receptor binding as a marker of osteoclast heterogeneity in osteopetrotic rodents. J Bone Min Res 1:543–553
Sieff CA, Levinsky RJ, Rogers DW, Muller K, Chessells JM, Pritchard J, Casey A, Hall CM (1983) Allogeneic bone-marrow transplantation in infantile malignant osteopetrosis. Lancet I:437–441
Shapiro F, Key LL, Anast C (1988) Variable osteoclast appearance in human infantile osteopetrosis. Calcif Tissue Int 43:67–76
Sorell M, Kapoor N, Kirkpatrick D, Rosen JF, Chaganti RSK, Lopez C, Dupont B, Pollack MS, Terrin BN, Harris MB, Vine D, Rose JS, Goosen C, Lane J, Good RA, O'Reilly RJ (1981) Marrow transplantation for juvenile osteopetrosis. Am J Med 70:1280–1287
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van Lie Peters, E.M., Aronson, D.C., Everts, V. et al. Failure of calcitriol treatment in a patient with malignant osteopetrosis. Eur J Pediatr 152, 818–821 (1993). https://doi.org/10.1007/BF02073378
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DOI: https://doi.org/10.1007/BF02073378