Abstract
Five infants, three girls and two boys, first had convulsions between the ages of 4 and 6 months. Although the aetiology of the attacks was unknown, all the infants had a family history of similar convulsions occurring at the same age and having a benign outcome. The attacks, which always occurred in a cluster, were promptly controlled, in four cases with phenobarbital and in one case with valproate. Seizures were partial with secondary generalization and were characterized by head and eye deviation (not always the same side in each attack) diffuse hypertonia and then bilateral limb jerks. The interictal EEG was normal. The ictal EEG showed diffuse discharge with onset in the central-occipital region. Laboratory, radiological and neurological findings were normal. A history in at least one paternal relative (the father in four cases) of similar seizures, occurring at the same age suggested a genetic predisposition. No seizures or EEG anomalies were observed during the follow up.
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References
Bankier A, Turner M, Hopkins J (1983) Pyridoxine dependent seizures: a wider clinical spectrum. Arch Dis Child 58:415–418
Commission on Classification and Terminology of the International League Against Epilepsy (1989) Proposal for revised classifications of epilepsies and epileptic syndromes. Epilepsia 30:389–399
Dulac O, Cusmai R, Oliveira K de (1989) Is there a partial benign epilepsy in infancy?. Epilepsia 30:798–801
Fukuyama Y (1963) Borderland of epilepsy with special reference to febrile convulsions and so called infantile convulsions. Clin Psychiatry 5:211–223
Goutières F, Aicardi J (1985) Atypical presentations of pyridoxine-dependent seizures: a treatable cause of intractable epilepsy in infants. Ann Neurol 17:117–120
Leppert M, Anderson VE, Quattlebaum T, Stauffer D, O'Connel P, Nakamura Y, Lalouel JM, White R (1989) Benign familial neonatal convulsions linked to genetic markers on chromosome 20. Nature 337:647–648
Miles KD, Holmes GL (1990) Benign neonatal seizures. J Clin Neurophysiol 7:369–379
Plouin P (1985) Benign neonatal convulsions (familial and non-familial). In: Roger J, Dravet C, Bureau M, Dreifuss FE, Wolf P (eds) Epileptic syndromes in infancy, childhood and adolescence. John Libbey Eurotext, London, pp 2–11
Vigevano F, Di Capua M, Fusco L, Ricci S, Sebastianelli R, Lucchini P (1990) “Sixth-month benign familial convulsions”. Epilepsia 31:613
Watanabe K, Yamamoto N, Negoro T, Takahashi I, Aso K, Machara M (1990) Benign infantile epilepsy with complex partial seizures. J Clin Neurophysiol 7:409–416
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Vigevano, F., Fusco, L., Di Capua, M. et al. Benign infantile familial convulsions. Eur J Pediatr 151, 608–612 (1992). https://doi.org/10.1007/BF01957732
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DOI: https://doi.org/10.1007/BF01957732