Skip to main content
SpringerLink
Log in

A case of rhinoscleroma cured with ciprofloxacin

Heilung eines Falles von Rhinosklerom mit Ciprofloxacin

  • Case Report
  • Published:
Infection Aims and scope Submit manuscript

Summary

The diagnosis of rhinoscleroma was confirmed in a 17-year-old female patient from Tehran, Iran, suffering from a roundish tumour of the nose. Prior treatment with streptomycin and tetracycline had been unsuccessful. A three-month course of high-dose oral ciprofloxacin (750 mg b. i. d.) led to prompt cessation of the growth of the granuloma which was removed later by plastic surgery. Although serology alone appeared to have little value for the specific diagnosis of rhinoscleroma, a significant increase of IgG antibodies during treatment with ciprofloxacin confirmed infection byKlebsiella rhinoscleromatis in this case.

Zusammenfassung

Bei einer 17jährigen Patientin aus Teheran/Iran, die sich wegen einer tumorösen Raumforderung der Nase vorstellte, wurde histologisch die Diagnose eines Rhinoskleroms gesichert. Da vorangegangene Behandlungen mit Streptomycin und Tetrazyklinen erfolglos geblieben waren, wurde ein Therapieversuch mit hochdosiertem Ciprofloxacin (2 × 750 mg/d p. o.) unternommen. Unter der Therapie kam es zu einem raschen Wachstumsstillstand des Granuloms, das später chirurgisch entfernt wurde. Serologische Untersuchungen zeigten einen signifikanten Anstieg von IgG-Antikörpern gegenKlebsiella rhinoscleromatis unter der Therapie. Die Patientin ist seit mehr als drei Jahren symptomlos.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. DiBartolomeo, J. R. Scleroma of the nose and pharynx. West. J. Med. 124 (1976) 13–17.

    Google Scholar 

  2. Goldberg, S. N., Canalis, R. F. Rhinoscleroma as a cause of airway obstruction. Ear Nose Throat J. 59 (1980) 145–149.

    Google Scholar 

  3. Wahi, A. L., Misra, R. N. A note on the geographical distribution of scleroma. J. Laryngol. Otol. 78 (1964) 573–576.

    Google Scholar 

  4. Hoffmann, E. O., Loose, L. D., Harkin, J. C. The Mikulicz cell in rhinoscleroma: light, fluorescent, and electron microscopic studies. Am. J. Pathol. 73 (1973) 47–58.

    Google Scholar 

  5. Meyer, P. R., Shum, T. K., Becker, T. S., Taylor, C. R. Scleroma (rhinoscleroma). A histologic immunohistochemical study with bacteriological correlates. Arch. Pathol. Lab. Med. 107 (1983) 377–383.

    Google Scholar 

  6. Toppozada, H., Mazloum, H., El-Sawy, M., Malaty, R., Yakout, Y. The complement fixation test in rhinoscleroma. J. Laryngol. Otol. 97 (1983) 55–57.

    Google Scholar 

  7. Shum, T. K., Whitaker, C. W., Meyer, P. R. Clinical update on rhinoscleroma. Laryngoscope 92 (1982) 1149–1155.

    Google Scholar 

  8. Rissing, J. P., Buxton, T. B., Moore, W. L. III, Ozawa, T., Moore, W. L. Jr. Enzyme-linked immunospecific antibody test for detecting antibody toKlebsiella. J. Clin. Microbiol. 8 (1978) 704–707.

    Google Scholar 

  9. Granström, M., Wretlind, B., Markman, B., Cryz, S. J. Enzyme-linked immunosorbent assay to evaluate the immunogenicity of a polyvalentKlebsiella capsular polysaccharide vaccine in humans. J. Clin. Microbiol. 26 (1988) 2257–2261.

    Google Scholar 

  10. Quevedo, J. Scleroma in Guatemala, with a study of the disease based on the experience of 108 cases. Ann. Otol. Rhinol. Laryngol. 58 (1949) 613–645.

    Google Scholar 

  11. Cone, L. A., Barton, S. M., Woodard, D. R. Treatment of scleroma with ceforanide. Arch. Otolaryngol. Head Neck Surg. 113 (1987) 374–376.

    Google Scholar 

  12. Wise, R., Andrews, J. R., Edwards, L. J. In vitro activity of Bay 09867, a new quinolone derivative, compared with those of other antimicrobial agents. Antimicrob. Agents Chemother. 23 (1983) 559–564.

    Google Scholar 

  13. Easmon, C. S. F., Crane, J. P. Uptake of ciprofloxacin by human neutrophils. J. Antimicrob. Chemother. 16 (1985) 67–73.

    Google Scholar 

  14. Easmon, C. S. F., Crane, J. P. Uptake of ciprofloxacin by macrophages. J. Clin. Pathol. 38 (1985) 442–444.

    Google Scholar 

  15. Montgomerie, J. Z. Epidemiology ofKlebsiella and hospital-associated infections. Rev. Infect. Dis. 1 (1979) 736–753.

    Google Scholar 

  16. Ørskow, I., Ørskov, F. Serotyping ofKlebsiella. In:Bergan, T. (ed.): Methods in Microbiology, vol. 14. Academic Press, London, Orlando, San Diego (1984) pp. 143–164.

    Google Scholar 

  17. Slopek, S. Klebsiella. In:Sedlak, J., Rische, H. (eds.): Enterobacteriaceae-Infektionen. Leipzig: Georg Thieme Verlag (1968) pp. 531–557.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Institut für Mikrobiologie, Abt. Bakteriologie, Universität Ulm, Steinhövelstr. 9, D-89075, Ulm

    M. Trautmann

  2. Abt. Infektiologie, Germany

    Th. Held &  M. Ruhnke

  3. Institut für Pathologie, Klinikum Rudolf Virchow/Charlottenburg, Freie Universität Berlin, Spandauer Damm 130, D-14046, Berlin, Germany

    N. Schnoy

Authors
  1. M. Trautmann
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Th. Held
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. M. Ruhnke
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. N. Schnoy
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Trautmann, M., Held, T., Ruhnke, M. et al. A case of rhinoscleroma cured with ciprofloxacin. Infection 21, 403–406 (1993). https://doi.org/10.1007/BF01728925

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01728925

Keywords

Search

Navigation