Skip to main content
Log in

Human herpesvirus 6 and human herpesvirus 7 infections in renal transplant recipients and healthy adults in Turkey

  • Brief Report
  • Published:
Archives of Virology Aims and scope Submit manuscript

Summary

We explored the prevalence of human herpesvirus 6 (HHV-6) and human herpesvirus 7 (HHV-7) infections in 16 renal transplant recipients and 16 healthy controls by virus isolation, serology, polymerase chain reaction (PCR) followed by dot blot hybridization. HHV-6 variant A was isolated from one renal transplant recipient. Seven patients (44%) and six controls (38%) had HHV-6 variant B DNA in their peripheral blood mononuclear cells. The prevalence of HHV-7 DNA was found to be the same in patients and controls (19%).

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. Ablashi DV, Agut H, Berneman Z, Campadelli-Fiume G, Carrigan D, Ceccerini-Nelli L, Chandran B, Chou S, Collandre H, Cone R, Dambaugh T, Dewhurst S, DiLuca D, Foa-Tomasi L, Fleckenstein B, Frenkel N, Gallo R, Gompels U, Hall C, Jones M, Lawrence G, Martin M, Montagnier L, Neipel F, Nicholas J, Pellet P, Razzaque A, Torelli G, Thomson B, Salahuddin S, Wyatt L, Yamanishi K (1993) Human herpesvirus-6 strain groups: a nomenclature. Arch Virol 129: 363–366

    PubMed  Google Scholar 

  2. Armstrong JA, Evans AS, Rat N, Ho M (1976) Viral infections in renal transplant recipients. Infect Immun 14: 970–975

    PubMed  Google Scholar 

  3. Berneman ZS, Ablashi DV, Li G, Eger-Fletcher M, Reitz JMS, Hung C-L, Brus I, Komaroff AL, Gallo RC (1992) Human herpesvirus 7 is a T-lymphotropic virus and is related to, but significantly different from, human herpesvirus 6 and human cytomegalovirus. Proc Natl Acad Sci USA 89: 10552–10556

    PubMed  Google Scholar 

  4. Berneman ZN, Gallo RC, Ablashi DV, Frenkel N, Katsafanas G, Kramarsky B, Brus I (1992) Human herpesvirus 7 (HHV-7) strain JI: Independent confirmation of HHV-7. J Infect Dis 166: 690–691

    PubMed  Google Scholar 

  5. Bovenzi P, Mirandola P, Secchiero P, Strumia R, Cassai E, DiLuca D (1993) Human herpesvirus 6 (variant A) in Kaposi's sarcoma. Lancet 341: 1288–1289

    Google Scholar 

  6. Clark DA, Freeland JM, Mackie PL, Jarrett RF, Onions DE (1993) Prevalence of antibody to human herpesvirus 7 by age. J Infect Dis 168: 251–252

    PubMed  Google Scholar 

  7. Cone RW, Huang MW, Ashley R, Corey L (1993) Human herpesvirus 6 DNA in peripheral blood cells and saliva from immunocompetent individuals. J Clin Microbiol 31: 1262–1267

    PubMed  Google Scholar 

  8. Dewhurst S, McIntryre K, Schnabel K, Hall CB (1993) Human herpesvirus 6 (HHV-6) variant B accounts for the majority of symptomatic primary HHV-6 infections in a population of U.S. infants. J Clin Microbiol 31: 416–418

    PubMed  Google Scholar 

  9. Drobysky WR, Eberle M, Majewski D, Baxter-Lowe LA (1993) Prevalence of human herpesvirus 6 variant A and B infections in bone marrow transplant recipients as determined by polymerase chain reaction and sequence-specific oligonucleotide probe hybridization. J Clin Microbiol 31: 1515–1520

    PubMed  Google Scholar 

  10. Frenkel N, Schirmer EC, Wyatt LS, Katsafanas G, Roffman E, Danovich RM, June CH (1990) Isolation of a new herpesvirus from human CD4+ T cells. Proc Natl Acad Sci USA 87: 748–752

    PubMed  Google Scholar 

  11. Frenkel N, Wyatt LS (1992) HHV-6 and HHV-7 as exogenous agents in human lymphocytes. Dev Biol Stand 76: 259–265

    PubMed  Google Scholar 

  12. Gopal MR, Thomson BJ, Fox J, Tedder RS, Honess RW (1990) Detection by PCR of HHV-6 and EBV DNA in blood and oropharynx of healthy adults and HIV-seropositive. Lancet 335: 1598–1599

    PubMed  Google Scholar 

  13. Grundy JE (1990) Virologic and pathogenic aspects of cytomegalovirus infection. Rev J Infect Dis 12: 711–719

    Google Scholar 

  14. Jablonsky E, Moomaw EW, Tullis H, Ruth LJ (1986) Preparation of oligodeoxynucleotide-alkaline phosphatase conjugates and their use as hybridization probes. Nucleic Acids Res 14: 6115–6128

    PubMed  Google Scholar 

  15. Josephs SF, Henry B, Balachandran N, Strayer D, Peterson D, Komaroff AL, Ablashi DV (1991) HHV-6 reactivation in chronic fatigue syndrome. Lancet 337: 1346–1347

    PubMed  Google Scholar 

  16. Martin MD, Nicholas J, Thomson BJ, Newman C, Honess RW (1991) Identification of a transactivating function mapping to the putative immediate-early locus of human herpesvirus 6. J Virol 65: 5381–5390

    PubMed  Google Scholar 

  17. Okuno T, Takahashi K, Balachandra K, Shiraki K, Yamanishi K, Takahashi M, Baba K (1989) Seroepidemiology of human herpesvirus 6 infection in normal children and adults. J Clin Microbiol 27: 651–653

    PubMed  Google Scholar 

  18. Okuno T, Higashi K, Shiraki K, Yamanishi K, Takahashi M, Kokado Y, Ishibashi M, Takahara S, Sonoda T, Tanaka K, Baba K, Yabuuchi H, Kurata T (1990) Human herpesvirus 6 infection in renal transplantation. Transplantation 49: 519–522

    PubMed  Google Scholar 

  19. Okuno T, Shao H, Asada H, Shiraki K, Takahashi M, Yamanishi K (1990) Analysis of a glycoprotein of human herpesvirus 6 (HHV-6) using monoclonal antibodies. Virology 176: 625–628

    PubMed  Google Scholar 

  20. Pruksananonda P, Hall CB, Insel RA, McIntyre K, Pellett PE, Long CE, Schnabel KC, Pincus PH, Stamey FR, Dambaugh TR, Stewart JA (1992) Primary human herpesvirus 6 infection in young children. N Engl J Med 326: 1445–1450

    PubMed  Google Scholar 

  21. Salahuddin SZ, Ablashi DV, Markham PD, Josephs SF, Sturnezegger S, Kaplan M, Halligan G, Biberfeld G, Wong-Staal F, Kramarsky B, Gallo RC (1986) Isolation of a new virus, HBLV, in patients with lymphoproliferative disorders. Science 234: 596–601

    PubMed  Google Scholar 

  22. Saxinger C, Polesky H, Eby N, Grufferman S, Murphy R, Tegtmeir G, Parekh V, Memon S, Hung C (1988) Antibody reactivity with HBLV (HHV-6) in US populations. J Virol Methods 21: 199–208

    PubMed  Google Scholar 

  23. Takahashi K, Segal E, Kondo T, Mukai T, Moriyama M, Yamanishi K (1992) Interferon and natural killer cell activity in patients with exanthem subitum. Pediatr Infect Dis 11: 369–373

    Google Scholar 

  24. Ward KN, Gray JJ, Efstathiou S (1989) Brief report: primary human herpesvirus infection in a patient following liver transplantation from a seropositive donor. J Med Virol 28: 69–72

    PubMed  Google Scholar 

  25. Wyatt LS, Rodriguez WJ, Balachandran N, Frenkel N (1991) Human herpesvirus 7: antigenic properties and prevalence in children and adults. J Virol 65: 6260–6265

    PubMed  Google Scholar 

  26. Wyatt LS, Frenkel N (1992) Human herpesvirus 7 is a constitutive inhabitant of adult human saliva. J Virol 66: 3206–3209

    PubMed  Google Scholar 

  27. Yamanishi K, Okuno T, Shiraki K, Takahashi M, Kondo K, Asano Y, Kurata T (1988) Identification human herpesvirus-6 as a casual agent for exanthem subitum. Lancet i: 1065–1067

    Google Scholar 

  28. Yoshikawa T, Suga S, Asano Y, Nakashima T, Yazaki T, Ono Y, Fujita T, Tsuzuki K, Sugiyama S, Oshima S (1992) A prospective study of human herpesvirus-6 infection in renal transplantation. Transplantation 54: 879–883

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Yalcin, S., Karpuzglu, T., Suleymanlar, G. et al. Human herpesvirus 6 and human herpesvirus 7 infections in renal transplant recipients and healthy adults in Turkey. Archives of Virology 136, 183–190 (1994). https://doi.org/10.1007/BF01538827

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01538827

Keywords

Navigation