Summary
A report is given of a woman who developed acute idiopathic polyradiculoneuritis and was found at necropsy 9 weeks later to have in addition multiple recent demyelinated lesions in the central nervous system (CNS), resembling those of multiple sclerosis (MS). The possibility that in such a case there might be an immunological reaction against one or more components of myelin common to the CNS and PNS has to be considered.
Similar content being viewed by others
References
Asbury AK (1981) Diagnostic considerations in the Guillain-Barré syndrome. Ann Neurol [Suppl] 9:1–5
Asbury AK, Arnason BG, Adams RD (1969) The inflammatory lesion in idiopathic polyneuritis: its role in pathogenesis. Medicine (Baltimore) 48:173–215
Brostoff SW, Powers JM, Weise MJ (1980) Allergic encephalomyelitis induced in guinea pigs by a peptide from the NH2-terminus of bovine P2 protein. Nature 285:103–104
Forrester C, Lascelles RG (1979) Association between polyneuritis and multiple sclerosis. J Neurol Neurosurg Psychiatry 42:864–866
Hasson J, Terry RD, Zimmerman HM (1958) Peripheral neuropathy in multiple sclerosis. Neurology 8:503–510
Haymaker W, Kernohan JW (1949) The Landry-Guillain-Barré syndrome: a clinicopathologic report of fifty fatal cases and a critique of the literature. Medicine (Baltimore) 28:59–141
Kadlubowski M, Hughes RAC (1980) The neuritogenicity and encephalitogenicity of P2 in the rat, guinea-pig and rabbit. J Neurol Sci 48:171–178
Keuter EJW (1967) Polyneuritis and multiple sclerosis. Psychiatr Neurol Neurochir 70:271–279
Lassmann H, Budka H, Schnaberth G (1981) Inflammatory demyelinating polyradiculitis in a patient with multiple sclerosis. Arch Neurol 38:99–102
Leibowitz S, Hughes RAC (1983) Immunology of the nervous system. Arnold, London, p 115
Lumsden CE (1972) The clinical pathology of multiple sclerosis. In: McAlpine D, Lumsden CE, Acheson ED (eds) Multiple sclerosis: a reappraisal, 2nd ed. Churchill Livingstone, Edinburgh London, pp 314–316
Madrid RE, Wisniewski HM (1978) Peripheral nervous system pathology in relapsing experimental allergic encephalomyelitis. J Neurocytol 7:265–282
Marburg O (1906) Die sogenannte akute multiple Sklerose. Jahrb Psychiat (Neurol) 27:211–312
Pender MP, Sears TA (1984) The pathophysiology of acute experimental allergic encephalomyelitis in the rabbit. Brain 107:699–726
Pette H (1928) Klinische und anatomische Studien über die Pathogenese der multiplen Sklerose. Dtsch Z Nervenheilkd 105:76–132
Phadke JG, Best PV (1983) Atypical and clinically silent multiple sclerosis: a report of 12 cases discovered unexpectedly at necropsy. J Neurol Neurosurg Psychiatry 46:414–420
Phillips MS, Stewart S, Anderson JR (1984) Neuropathological findings in Miller-Fisher syndrome. J Neurol Neurosurg Psychiatry 47:492–495
Pollock M, Calder C, Allpress S (1977) Peripheral nerve abnormality in multiple sclerosis. Ann Neurol 2:41–48
Raine CS, Wisniewski H, Prineas J (1969) An ultrastructural study of experimental demyelination and remyelination. II. Chronic experimental allergic encephalomyelitis in the peripheral nervous system. Lab Invest 21:316–327
Richter RB (1962) The ataxic form of polyradiculoneuritis (Landry-Guillain-Barré syndrome). J Neuropathol Exp Neurol 21:171–184
Ro YI, Alexander CB, Oh SJ (1983) Multiple sclerosis and hypertrophic demyelinating peripheral neuropathy. Muscle Nerve 6:312–316
Ropper AH (1983) The CNS in Guillain-Barré syndrome. Arch Neurol 40:397–398
Rosenberg NL, Bourdette D (1983) Hypertrophic neuropathy and multiple sclerosis. Neurology 33:1361–1364
Rosenblum WI, Budzilovich G, Feigin I (1966) Lesions of the spinal cord in polyradiculoneuropathy of unknown aetiology and a possible relationship with the Guillain-Barré syndrome. J Neurol Neurosurg Psychiatry 29:69–76
Schoene WC, Carpenter S, Behan PO, Geschwind N (1977) “Onion-bulb” formations in the central and peripheral nervous system in association with multiple sclerosis and hypertrophic polyneuropathy. Brain 100:755–773
Wisniewski H, Prineas J, Raine CS (1969) An ultrastructural study of experimental demyelination and remyelination. I. Acute experimental allergic encephalomyelitis in the peripheral nervous system. Lab Invest 21:105–118
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Best, P.V. Acute polyradiculoneuritis associated with demyelinated plaques in the central nervous system: Report of a case. Acta Neuropathol 67, 230–234 (1985). https://doi.org/10.1007/BF00687806
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00687806