Summary
The acceptance by children of two pharmacologically identical phenoxymethyl-penicillin potassium and erythromycin ethylsuccinate mixtures, differing only in their flavouring agents, was compared in a randomised blind manner. The time a nurse required to give the drug to a child was recorded and a score of the acceptance was given by the nurse. The mean time to give erythromycin Brand 1 was 29 s (SD±21, number of children=20) and mean time to give Brand 2 it was 16 s (SD±13,n=18); the difference was significant (p<0.05). The mean scores were 2.9 (SD±0.025). The difference between the two penicillin products was not significant. The time required to give a medicine was a useful way to compare the effect of different flavouring mixtures on the acceptance of drugs by infants and children.
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References
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Uhari, M., Eskelinen, L. & Jokisalo, J. Acceptance of antibiotic mixtures by infants and children. Eur J Clin Pharmacol 30, 503–504 (1986). https://doi.org/10.1007/BF00607970
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DOI: https://doi.org/10.1007/BF00607970