Abstract
Blood volume was estimated using 51chromium labelled red cells and 125iodinated human serum albumin in 5 children with sepsis, in 6 burned children and 7 children with acute lymphoblastic leukaemia. Studies of the equilibration pattern demonstrated that the mixing time of labelled red cells was prolonged to 40 minutes or more in 5 children, indicating the existence of slowly circulating red cells. Mixing of labelled albumin was complete within 10 minutes in 15 patients and within 20 minutes in all the children studied. In a burned patient with severe sepsis, exchange transfusion improved the clinical state and normalized the equilibration pattern of labelled red cells. The mean body/venous haematocrit ratio was 0.893±0.018 (SD) in the children with sepsis, 0.859±0.052 in the burned patients, and 0.916±0.078 in the children with acute lymphoblastic leukaemia, increasing with spleen size in the latter group.
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Linderkamp, O., Holthausen, H., Seifert, J. et al. Accuracy of blood volume estimations in critically I11 children using 125I-labelled albumin and 51Cr-labelled red cells. Eur J Pediatr 125, 143–151 (1977). https://doi.org/10.1007/BF00489987
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DOI: https://doi.org/10.1007/BF00489987