Abstract
We present a six years follow up of a 6 1/2 year-old boy with recurrent aphasia, sporadic emotional regression and a convulsive disorder. The electroencephalogram reading during sleep showed continuous, generalized, hypersynchronous activity without clinical evidence of seizure (“subclinical bioelectric status epilepticus”). Clinical, laboratory and instrumental data revealed no evidence of a morphological lesion of the brain, either spaceoccupying, inflammatory, degenerative, or autoimmune. Remissions occured with and without anticonvulsant and steroid therapy. The hypothetical location, type, and etiology of the process are discussed. The syndrome appears to represent a functional disorganisation of speech-controlling areas of the brain.
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Brodal, A.: Neurological anatomy in relation to clinical medicine. 2. Ed. New York-London-Toronto: Oxford University Press Inc. 1974
Deonna, Th., Beaumanoir, A., Gaillard, F., Assal, G.: Acquired Aphasia in Childhood with Seizure disorder: A heterogeneous syndrome. Neuropädiatrie 8, 263–273 (1977)
Duffy, T. E., Howse, D. C., Plum, F.: Cerebral Energy Metabolism during Experimental status Epilepticus. J. Neurochem. 24, 925–934 (1975)
McKinney, W., McGreal, D. A.: An aphasic syndrome in children. Canad. Med. Ass. J. 110, 637–639 (1974)
Landau, W. M., Kleffner, F. R.: Syndrome of acquired aphasia with convulsive disorder in children. Neurology 7, 523–530 (1957)
Ojemann, G. A., Ward, A. A.: Speech representation in ventrolateral thalamus. Brain 94, 669–680 (1971)
Patry, G., Lyagoubi, S., Tassinari, C. A.: Subclinical “electrical status epilepticus” induced by sleep in children. Arch. Neurol. 24, 242–252 (1971)
Pötzl, O.: Über sensorische Aphasie, im Kindesalter. Z. Hals-, Nasen-und Ohrenheilk. 14, 190–216 (1926)
Rose, F. C.: Receptive aphasia in childhood. J. Neurol. Neurosurg. Psychiat. 32, 65 (1969)
Tassinari, C. A., Dravet, C., Roger, J.: Encephalopathy related to electrical status epilepticus during slow sleep. Electroenc. Clin. Neurophysiol. 43, 529–530 (1977)
Wasterlain, C. G.: Inhibition of cerebral protein synthesis by epileptic seizures without motor manifestations. Neurology 24, 175–180 (1974)
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Kellermann, K. Recurrent aphasia with subclinical bioelectric status epilepticus during sleep. Eur J Pediatr 128, 207–212 (1978). https://doi.org/10.1007/BF00444306
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DOI: https://doi.org/10.1007/BF00444306