Clinical Immunology and Immunopathology
Volume 79, Issue 2, May 1996, Pages 105-114
Short Analytical ReviewSelection of Ligands for Polyclonal Antibodies from Random Peptide Libraries: Potential Identification of (Auto)Antigens That May Trigger B and T Cell Responses in Autoimmune Diseases
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The nature of target-unrelated peptides recovered in the screening of phage-displayed random peptide libraries with antibodies
2005, Analytical BiochemistryCitation Excerpt :They represent a significant handicap in applications in which serum or purified total IgGs are used as targets (e.g., if IgGs from donors having a particular disease are used to identify ligands that act as serologic markers for that disease). In these cases, reduction of TUP can be achieved by preadsorption of the input phage with IgGs from healthy donors, as was done by Sioud et al. [74]. Selection of phage by xenoreactive antibodies present in human sera may be prevented by the use of carbohydrates having the Gal(α1,3)Gal epitope (e.g., melibiose, Galili et al. [49]) in the phage–target incubation step.
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