Table 1

Baseline characteristics of the 90 children randomised

CharacteristicHyoscineGlycopyrroniumTotal
n=49n=41n=90
Sex
 Female16 (33%)19 (46%)35 (39%)
 Male33 (67%)22 (54%)55 (61%)
 Age at randomisation
 Median (years)4.94.64.9
 Range(3.0, 14.5)(3.0, 11.9)(3.0, 14.5)
Weight
 Median (kg)18.116.618.1
Range(11.1, 79.4)(10.4, 41.8)(10.4, 79.4)
Children with cerebral palsy10 (20%)12 (29%)22 (24%)
Severity of drooling*
 Saliva usually on clothes43 (88%)35 (85%)78 (87%)
 Saliva usually on face6 (12%)6 (15%)12 (13%)
Baseline Drooling Impact Scale
 n473986
 Mean (SD)57.9 (15.5)52.1 (12.7)55.3 (14.5)
 Median (Range)58 (26, 85)53 (25, 75)54.5 (25, 85)
Baseline Drooling Severity and Frequency Scale†
 n353368
 Mean (SD)7.6 (1.1)7.6 (1.1)7.6 (1.1)
 Median (Range)8 (5, 9)(5, 9)8 (5, 9)
  • *Stratification factor at randomisation.

  • †Baseline scores for those whose treatment was tolerated to week-4.