Table 3

Secondary outcomes

SMC groupSMC plus LP groupCrude difference in means (95% CI), p valueAdjusted difference in means* (95% CI), p valueNAdjusted difference in means† (95% CI), p valueN
MeanNMeanN
Chalder Fatigue score 6 months‡ 19.83714.444−5.4 (−8.6 to 2.1), 0.001−4.7 (−7.9 to 1.6), 0.00380−5.4 (−8.9 to 1.9), 0.00376
Chalder Fatigue score 12 months‡15.73812.342−3.4 (−6.6 to 0.1), 0.041−3.2 (−6.3 to 0.1), 0.04579−4.0 (−7.2 to 0.7), 0.01774
Pain VAS 6 months‡32.82823.433−9.5 (−23.5 to 4.6), 0.183−11.3 (−23.0 to 0.3), 0.05758−9.3 (−21.1 to 2.6), 0.12458
Pain VAS 12 months‡32.02721.832−10.2 (−24.6 to 4.2), 0.161−9.4 (−21.5 to  2.7), 0.12556−6.5 (−19.4 to 6.5), 0.32154
SCAS 6 months‡37.42824.733−12.7 (−22.0 to 3.3), 0.009−8.7 (−16.9 to 0.5), 0.03961−10.0 (−18.5 to 1.5), 0.02258
SCAS 12 months‡36.32719.631−16.7 (−25.9 to 7·5), 0.001−12.1 (−20.1 to 4.1), 0.00456−14.5 (−22.4 to 6.7),<0.00152
HADS anxiety score 6 months‡9.7286.133−3.7 (−6.0 to 1·3), 0.003−3.3 (−5.6 to 1.0), 0.00560−3.5 (−5.6 to 1.5), 0.00157
HADS anxiety score 12 months‡8.3275.333−3.1 (−5.2 to 0.9), 0.006−2.8 (−4.7 to 0.8), 0.00659−2.6 (−4.7 to 0.4), 0.01953
HADS depression score 6 months‡5.9284.233−1.7 (−4.0 to  0.6), 0.141−1.6 (−3.9 to 0.7), 0.16159−1.5 (−3.5 to 0.5), 0.12957
HADS depression score 12 months‡4.6272.833−1.9 (−3.6 to 0.2), 0.033−1.7 (−3.3 to 0.2), 0.03058−1.8 (−3.4 to 0.1), 0.03753
School/college attendance in the previous week 6 months§ (days)2.6373.2410.7 (−0.1 to 1.4), 0.0830.7 (0.0 to  1.4), 0.064770.6 (−0.2 to 1.4), 0.13572
School/college attendance in the previous week 12 months§ (days)3.1364.1341.0 (0.2 to 1.7), 0.0100.9 (0.2 to 1.6), 0.018691.0 (0.2 to 1.8), 0·01265
  • *Adjusted for age, gender and baseline outcome.

  • †Higher score=more symptoms, poorer function.

  • ‡Adjusted for age, gender, baseline outcome, baseline SCAS and VAS (as appropriate).

  • §Higher score=fewer symptoms, better function.

  • HADS, Hospital Anxiety and Depression Scale; LP, Lightning Process; SCAS, Spence Children’s Anxiety Scale; SF-36: The 36-Item Short-Form Health survey; SMC, specialist medical care; VAS, Visual Analogue Scale.