Paediatric FH Register characteristics* at baseline by age
| ≤10 years N=96† | >10 years N=111† | ||
|---|---|---|---|
| Number boys/girls (%age boys) | 50/46 (52.1) | 54/57 (48.7) | |
| Age (years) | Mean (SD) N Median (IQR) | 7.3 (2.2) 96 7.8 (5.5–9.1) | 12.6 (1.7) 111 12.6 (10.9–13.9) |
| Weight (kg) | Mean (SD) N Median (IQR) | 27.8 (9.5) 88 25.6 (21–34.1) | 50.3 (14.4) 102 49.1 (40.5–57.7) |
| Height (m) | Mean (SD) N Median (IQR) | 1.26 (14.2) 77 1.28 (1.17–1.37) | 1.56 (11.4) 91 1.55 (1.49–1.64) |
| Total cholesterol (mmol/L) | Mean (SD) N Median (IQR) | 8.07 (1.43) 96 8.0 (6.99–9.15) | 7.22 (1.43) 111‡ 7.1 (6.3–8.0) |
| LDL-C (mmol/L) | Mean (SD) N Median (IQR) | 6.17 (1.40) 87 6.1 (5.1–7.1) | 5.28 (1.39) 106§ 5.1 (4.4–6.1) |
| HDL-C (mmol/L) | Mean (SD) N Median (IQR) | 1.41 (0.35) 87 1.4 (1.13–1.65) | 1.41 (0.33) 105 1.4 (1.2–1.6) |
| Triglyceride (mmol/L) | Mean (SD) N Median (IQR) | 0.96 (0.47) 86 0.84 (0.7–1.1) | 1.04 (0.60) 103 0.90 (0.67–1.25) |
| Smoking | % (N) | 1.04% (1/96) | 2.7% (3/110) |
There are 31 adolescent girls on statins. Five do not have oral contraceptive use recorded. Four of the remaining 26 (15%) were prescribed oral contraceptives.
*Excluding 3 patients with homozygous FH.
†25 children are missing diagnosis dates.
‡Cholesterol is significantly lower in age>10 years versus age<10 years, p=0.00006.
§LDL-C is significantly lower in age>10 years vs age<10 years, p=0.00001
FH, familial hypercholesterolaemia; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol.