Characteristics at diagnosis by age at diagnosis and subsequent statin use
| Age ≤10 years | Statin use | p Value (Mann-Whitney) | ||
|---|---|---|---|---|
| No N=51 | Yes N=45 | |||
| Age (years) | Mean (SD) Median (IQR) | 7.4 (2.0) 51 7.7 (5.6–8.9) | 7.1 (2.5) 45 7.8 (5.3–9.3) | 0.84 |
| Sex | % male | 47.1% (24/51) | 57.8% (26/45) | 0.29 (χ2) |
| Ethnicity | % Caucasian | 78.4 (40/51) | 84.4 (38/45) | 0.45 (χ2) |
| CHD in parent/first-degree relative | % yes | 15.7% (8/51) | 22.7% (10/44) | 0.38(χ2) |
| CHD in any relative | %yes | 33.3% (17/51) | 48.9% (22/45) | 0.12 (χ2) |
| CHD onset age in relative | Mean (SD) Median (IQR) | 33.9 (20.5) 17 40 (30–49) | 33.7 (16.8) 22 40 (23–44) | 0.68 |
| Mutation status | % yes | 58.7% (27/46) | 60.5% (26/43) | 0.87 (chi-square) |
| Diag weight (kg) | Mean (SD) Median (IQR) | 27.6 (9.5) 48 24.6 (21.4–32.5) | 27.9 (9.6) 40 27.4 (20.4–34.4) | 0.85 |
| Diag height (m) | Mean (SD) Median (IQR) | 1.25 (0.14) 43 1.27 (1.17–1.36) | 1.27 (0.14) 34 1.29 (1.20–1.38) | 0.64 |
| Diag cholesterol (mmol/L) | Mean (SD) Median (IQR) | 7.77 (1.42) 51 7.6 (6.8–8.4) | 8.40 (1.39) 45 8.5 (7.3–9.3) | 0.01 |
| Diag HDL-C (mmol/L) | Mean (SD) Median (IQR) | 1.44 (0.38) 47 1.4 (1.13–1.7) | 1.37 (0.31) 40 1.39 (1.13–1.59) | 0.62 |
| Diag triglyceride (mmol/L) | Mean (SD) Median (IQR) | 0.94 (0.54) 46 0.8 (0.64–1.1) | 0.99 (0.39) 40 0.9 (0.76–1.18) | 0.12 |
| Diag LDL-C (mmol/L) | Mean (SD) Median (IQR) | 5.83 (1.30) 48 5.8 (4.85–6.42) | 6.59 (1.42) 39 6.7 (5.5–7.7) | 0.008 |
| Follow-up weight (kg) | Mean (SD) Median (IQR) | 35.5 (14.3) 48 32.0 (25.1–42.6) | 43.8 (17.1) 44 37.2 (33.6–55.2) | 0.005 |
| Follow-up height (m) | Mean (SD) Median (IQR) | 1.34 (0.116) 41 1.37 (0.126–1.42) | 1.46 (0.18) 41 1.46 (1.38–1.57) | 0.0006 |
| Follow-up cholesterol (mmol/L) | Mean (SD) Median (IQR) | 7.34 (1.37) 48 7.2 (6.4–8.3) | 5.82 (0.92) 53 5.8 (5.1–6.3) | 1.484e-07 |
| Follow-up HDL-C (mmol/L) | Mean (SD) Median (IQR) | 1.42 (0.33) 43 1.4 (1.13–1.68) | 1.38 (0.37) 43 1.37 (1.16–1.52) | 0.47 |
| Follow-up triglyceride (mmol/L) | Mean (SD) Median (IQR) | 0.94 (0.54) 42 0.8 (0.6–1.2) | 0.91 (0.38) 42 0.82 (0.68–1.01) | 0.87 |
| Follow-up LDL-C (mmol/L) | Mean (SD) Median (IQR) | 5.47 (1.26) 45 5.3 (4.6–6.45) | 4.06 (0.97) 41 4.02 (3.3–4.6) | 1.316e-06 |
| Age>10 years | No N=46 | Yes N=65 | P value (Mann-Whitney) | |
|---|---|---|---|---|
| Age (years) | Mean (SD) Median (IQR) | 12.8 (1.7) 46 12.9 (11.1–14.0) | 12.5 (1.7) 65 12.2 (10.8–13.8) | 0.35 |
| Sex | % male | 50.0% (23/46) | 47.7% (31/65) | 0.81 (χ2) |
| Ethnicity | % Caucasian | 76.1 (35/46) | 83.1 (54/65) | 0.36 (χ2) |
| CHD in parent/first-degree relative | % yes | 23.9% (11/46) | 32.8% (21/64) | 0.31 (χ2) |
| CHD in any relative | %yes | 41.3% (19/46) | 49.2% (32/65) | 0.41 (χ2) |
| CHD onset age in relative | Mean (SD) Median (IQR) | 44.2 (11.5) 22 46 (36–52) | 41.8 (11.5) 35 40 (37–48) | 0.46 |
| Mutation status | % yes | 56.8% (21/37) | 71.2% (42/59) | 0.15 (χ2) |
| Diag weight (kg) | Mean (SD) Median (IQR) | 51.5 (13.1) 43 49.2 (41.9–59.4) | 49.4 (15.4) 59 48.6 (38–56.4) | 0.35 |
| Diag height (m) | Mean (SD) Median (IQR) | 1.58 (0.10) 39 1.56 (1.51–1.67) | 1.54 (0.12) 52 1.54 (1.48–1.64) | 0.23 |
| Diag cholesterol (mmol/L) | Mean (SD) Median (IQR) | 6.73 (1.37) 46 6.6 (5.8–7.5) | 7.57 (1.38) 65 7.43 (6.8–8.3) | 0.001 |
| Diag HDL-C (mmol/L) | Mean (SD) Median (IQR) | 1.42 (0.37) 42 1.35 (1.2–1.6) | 1.41 (0.30) 63 1.4 (1.2–1.6) | 0.81 |
| Diag triglyceride (mmol/L) | Mean (SD) Median (IQR) | 1.03 (0.58) 41 0.8 (0.7–1.2) | 1.04 (0.62) 62 0.9 (0.6–1.3) | 0.85 |
| Diag LDL-C (mmol/L) | Mean (SD) Median (IQR) | 4.76 (1.28) 44 4.65 (4–5.4) | 5.64 (1.37) 62 5.5 (4.7–6.4) | 0.0007 |
| Follow-up weight (kg) | Mean (SD) Median (IQR) | 55.4 (14.3) 44 52.9 (43.9–63.3) | 58.8 (14.7) 64 57.1 (50.9–62.7) | 0.22 |
| Follow-up height (m) | Mean (SD) Median (IQR) | 1.59 (0.10) 34 1.57 (1.53–1.65) | 1.63 (0.11) 53 1.63 (1.55–1.70) | 0.05 |
| Follow-up cholesterol (mmol/L) | Mean (SD) Median (IQR) | 6.52 (1.33) 46 6.3 (5.6–7.1) | 5.55 (1.22) 65 5.3 (4.72–6.3) | 0.0004 |
| Follow-up HDL-C (mmol/L) | Mean (SD) Median (IQR) | 1.44 (0.36) 45 1.43 (1.2–1.6) | 1.37 (0.27) 57 1.38 (1.2–1.5) | 0.36 |
| Follow-up triglyceride (mmol/L) | Mean (SD) Median (IQR) | 1.04 (0.49) 44 0.90 (0.7–1.30) | 0.97 (0.50) 58 0.82 (0.6–1.2) | 0.33 |
| Follow-up LDL-C (mmol/L) | Mean (SD) Median (IQR) | 4.55 (1.27) 44 4.3 (3.8–5.1) | 3.82 (1.21) 55 3.6 (2.9–4.8) | 0.006 |
CHD, coronary heart disease; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol.