One of: | Neurological deficit due to stroke or subarachnoid haemorrhage |
Recurrent acute chest syndrome not responding to 6-month course of hydroxycarbamide | |
Recurrent vaso-occlusive crises not responding to 6-month course of hydroxycarbamide | |
AND | <16 years |
AND | HLA-identical matched related donor available |
Candidates who may be considered for HSCT in special circumstances: | ▸ Problems relating to future medical care e.g. unavailability of adequately screened blood products ▸ SCD relapsing after previous HSCT ▸ Transfusion-dependent S/β0 thalassaemia ▸ Adults aged 17–35 years (as part of clinical trial) |
HLA, human leukocyte antigen; HSCT, haemopoietic stem cell transplant; SCD, sickle cell disease.