Scoring systems for predicting IVIG resistance
| EGAMI49 | KOBAYASHI47 | SANO50 | |
|---|---|---|---|
| Na ≤133 (2 points) | Total bilirubin ≥0.9 mg/dl (1 point) | ||
| ≤4 days of illness (1 point) | ≤4 days of illness (2 points) | ||
| ALT >100 U/L (1 point) | ALT≥ 100 U/L (1 point) | AST ≥200 U/L (1 point) | |
| ≤300 ×[109/L platelets (1 point) | ≤300×109 /L platelets (1 point) | ||
| CRP ≥8 mg/dL (1 point) | CRP≥10 mg/dL (1 point) | CRP≥7 mg/dL (1 point) | |
| Age ≤6 months (2 points) | Age ≤12 months (1 point) | ||
| ≥80% neutrophils (2 points) | |||
| High risk | ≥3 points | ≥5 points | ≥2 points |
| Test performance in Japanese vs non-Japanese | |||
| Japanese cases | |||
| Sensitivity (%) | 78 | 86 | 77 |
| Specificity (%) | 76 | 67 | 86 |
| Non-Japanese cases51 | |||
| Sensitivity (%) | 42 | 33 | 40 |
| Specificity (%) | 85 | 87 | 85 |
ALT, alanine aminotransferase; AST, aspartate aminotransferase; CRP, C-reactive protein; IVIG, intravenous immunoglobulin.47 ,49–51