Single propacetamol | Repeated propacetamol | Repeated paracetamol | Repeated paracetamol | |
---|---|---|---|---|
Allegaert et al13 | Allegaert et al15 | Palmer et al11 | New dataset, PARANEO | |
Samples (n) | 213 | 107 | 189 | 445 |
Patients (n) | 30 | 18 | 50 | 60 |
Route of sampling | Arterial | Arterial | Arterial/venous/capillary | Arterial |
Postnatal age (range, days) | 1 | 1–76 | 1–144 | 1–28 |
Postmenstrual age (range, weeks) | 27–40 | 29–43 | 31.7–45 | 27–42 |
Preterm (<37 weeks) | 20 | 4 | 11 | 23 |
Extreme preterm (<32 weeks) | 10 | 2 | 1 | 8 |
Weight (range) | 0.505–4 kg | 0.81–4 kg | 1.2–4.54 kg | 0.6–4.3 kg |
Low birth weight (<1500 g) | 10 | 3 | 1 | 9 |
Extreme low birth weight (<1000 g) | 6 | 2 | 1 | 4 |
Growth restricted (<10th percentile) | 10 | 3 | 11 | 7 |
Unconjugated bilirubinaemia (μmol/l) | 15.4–80.4 | 1.7–212 | 58–195 | 8.5–256 |
Main indication for intravenous paracetamol | ||||
Postoperative analgesia | 1/30 | 16/18 | 48/50 | 33/60 |
Cardiac surgery | 0 | 3 | 1 | 15 |
Thoracic surgery | 0 | 6 | 15 | 11 |
Abdominal surgery | 1 | 3 | 30 | 6 |
Other | 0 | 4 | 2 | 1 |
Medical conditions | 29/30 | 2/18 | 2/50 | 27/60 |
Fever | 0 | 0 | 0 | 3 |
Traumatic pain | 2 | 0 | 0 | 5 |
Alprostadil administration | 1 | 2 | 0 | 8 |
Procedural/respiratory | 26 | 0 | 0 | 8 |
Other | 0 | 0 | 2 | 3 |
PARANEO, paracetamol in neonates.