| Indomethacin (n = 96) | Ibuprofen (n = 100) | Student t test/ Chi squared test | |
|---|---|---|---|
| Gestation (mean ± SD) | 25.5 ± 1.7 wks | 25.8 ± 1.9 weeks | P = 0.18 |
| Birth weight (mean ± SD) | 773 ± 226g | 839 ± 227g | P= <0.05 |
| All NEC | 17 (17%) | 8 (8%) | P = 0.06 |
| Early NEC(<28 days) Late NEC(>28days) | 12 5 | 4 4 | P = 0.035 P = 0.73 |
| SIP | 4 (4%) | 4 (4%) | P= >0.99 |
| Died from gut pathology | 7 (35%) | 3 (25%) | P = 0.70 |
| PDA ligation | 22 (23%) | 22 (22%) | P = 0.98 |
| Died post ligation | 0 | 0 | |
| Gut pathology post ligation | 2 NEC | 1 intussusception | |
| Mortality | 13 (14%) | 10 (10%) | P = 0.58 |