Patient characteristics and clinical outcomes
| Period 1 | Period 2 | p | |
|---|---|---|---|
| N | 37 | 44 | |
| Birth weight (g) | 875 (710–940) | 820 (706–940) | 0.08 |
| Gestation (wk) | 26 (25–27) | 26 (25–27) | 0.85 |
| Symptomatic PDA | 13 35%) | 19 (43%) | 0.46 |
| Late treatment of PDA with IBU/IND | 6 (16%) | 15 (34%) | 0.07 |
| Duct ligation | 3 (8%) | 1 (2%) | 0.32 |
| Severe IVH (grade 3/4) | 6 (16%) | 8 (18%) | 1.0 |
| Chronic lung diease at 36 weeks PMA | 24 (65%) | 26 (60%) | 0.59 |
| Death | 11 (31%) | 13 (30%) | 0.92 |