Table 2

Diagnostic criteria for anaphylaxis as an adverse event following immunisation (AEFI). This table shows how the cases met Brighton Collaboration Case Definition (BCCD) criteria for anaphylaxis as an AEFI.5 The diagnosis rests upon the sudden onset and rapid progression of symptoms involving more than two organ systems. A case should also have at least one criterion from each designated system to meet the diagnosis

BCCD level of diagnostic certaintyDiagnostic criteriaNumber of cases meeting criteria
Level 11 major dermatological AND 1 major cardiovascular criterion
1 major dermatological AND 1 major respiratory criterion		2† 2†
Level 21 major cardiovascular AND 1 major respiratory criterion
1 major cardiovascular AND 1 minor criterion involving at least 1 different system (other than cardiovascular system)		0 1
1 major dermatological AND 1 minor cardiovascular criterion
1 major respiratory criterion AND 1 minor criterion involving at least 1 different system (other than respiratory system)
1 major dermatological AND 1 minor respiratory criterion		0 0 2
Level 31 minor cardiovascular OR respiratory criterion AND at least 1 minor criterion from each of two or more different systems1

  • ↵† One case had major respiratory and cardiovascular signs and met level 1 using both pathways.