Type of study | Frequency (N=105) | Number of patients (N=16 184) |
---|---|---|
Case series | 46 | 8876 |
Case report | 24 | 24 |
RCT | 15 | 1787 |
Cohort study | 12 | 5368 |
Pharmacokinetic | 5 | 79 |
Non-RCT | 3 | 50 |
Route of administration | Frequency (N=105) | Number of patients (N=16 184) |
Oral | 39 | 1871 |
Intravenous | 25 | 329 |
Intravenous and oral | 19 | 6489 |
Not reported | 16 | 6905 |
Topical | 6 | 590 |
Age group | Frequency (N)* | Number of patients† |
Children | 67 | NA |
Adolescents | 53 | NA |
Infants | 40 | NA |
Preterm neonates | 19 | NA |
Neonates (GA not stated) | 18 | NA |
Term Neonates | 9 | NA |
↵* Total number of studies for age group is not 105 studies because multiple age groups were included within some studies.
↵† The number of patients in each age group could not be ascertained because most studies involved more than one age group and the number within each age group was not reported.
GA, gestational age; NA, not available; RCT, randomised controlled trial.