Table 1

Demographics, biochemical parameters and sun exposure

		Supplementation
Parameter	Visit	250 IU/day (n=14)	500 IU/day (n=14)	p Value: 250 vs 500 IU
Gestation (weeks)		39 (39–40)	39 (39–40)	0.63
Weight (g)	Day 5	3763 (3492–3854)	3584 (3332–3835)	0.32
Weight (g)	6 weeks	4768 (4444–5092)^*	4195 (3882–4509)^*	0.02
Length (cm)	Day 5	52 (51–53)	52 (51–53)	0.69
Length (cm)	6 weeks	58 (57–59)	56 (55–57)	0.02
25(OH)D (nmol/l)	Day 5	68 (53–83)	68 (53–83)	0.99
25(OH)D (nmol/l)	6 weeks	139 (114–164)^*	151 (126–176)^*	0.48
Alkaline phosphatase (U/l)	Day 5	320 (276–378)	348 (300–396)	0.48
Alkaline phosphatase (U/l)	6 weeks	858 (720–996)^*	888 (750–1026)^*	0.78
Calcium (mmol/l)	Day 5	2.38 (2.29–2.47)	2.38 (2.29–2.47)	0.99
Calcium (mmol/l)	6 weeks	2.66 (2.58–2.73)^*	2.55 (2.47–2.62)^*	0.048
Phosphate (mmol/l)	Day 5	2.0 (1.9–2.2)	2.0 (1.9–2.2)	0.85
Phosphate (mmol/l)	6 weeks	2.2 (2.1–2.2)	2.1 (2.1–2.2)	0.33
Creatinine (μmol/l)	Day 5	38.4 (29.1–47.6)	38.3 (29.3–47.3)	0.1
Creatinine (μmol/l)	6 weeks	37.7 (31.6–43.8)	26.8 (19.9–32.2)^*	0.01
U-calcium (mmol/l)	Day 5	0.43 (0.1–0.75)	0.55 (0.25–0.86)	0.6
U-calcium (mmol/l)	6 weeks	1.54 (0.82–2.3)^*	1.45 (0.75–2.15)^*	0.85
U-phosphate (mmol/l)	Day 5	4.9 (0.85–8.9)	2.83 (1.0–6.8)	0.46
U-phosphate (mmol/l)	6 weeks	3.3 (0.3–6.8)	4.8 (1.4–8.2)	0.52
U-creatinine	Day 5	4621 (2673–6569)	5194 (3346–7042)	0.67
U-creatinine	6 weeks	769 (337–1201)^*	1062 (646–1478)^*	0.32
Ca/creatinine ratio	Day 5	159 (68–250)	145 (59–231)	0.82
Ca/creatinine ratio	6 weeks	1823 (1353–4999)^*	3898 (838–6959)^*	0.34
Sun exposure/day (h)		2.1 (1.6–2.6)	1.8 (1.3–2.4)	0.47
Sun exposure score		2.1 (1.8–2.4)	1.6 (1.3–1.9)	0.048
UVB exposure (MED/day)		0.05 (0.02–0.08)	0.03 (0.01–0.06)	0.37

Data are presented as mean and 95% CI. p Values refer to the comparison of daily supplementation with 250 vs 500 units of vitamin D3.
↵* Represent a significant difference between time points (day 5 vs 6 weeks, p<0.05).
MED, minimal erythema dose; UVB, ultraviolet B.