Table 4 Incidence proportions (%) and adjusted relative risks with 95% CI for lower respiratory tract infections (LRTI) and hospitalisations for LRTIs at different ages according to prenatal exposure to folic acid supplements for children born in 2000–2005
LRTI, 0–6 months,LRTI hospitalised,0–6 months,LRTI, 6–18 months,LRTI hospitalised,6–18 months,
n = 1566n = 614n = 4240n = 893
%aRR (95% CI)%aRR (95% CI)%aRR (95% CI)%aRR (95% CI)
Folic acid in first trimester
    No5.1%1.00 (–)1.8%1.00 (–)13.1%1.00 (–)2.8%1.00 (–)
    Yes5.1%1.11 (0.99 to 1.24)2.1%1.28 (1.06 to 1.55)13.7%1.08 (1.01 to 1.16)2.9%1.19 (1.02 to 1.40)
Folic acid after first trimester
    No5.3%1.00 (–)2.1%1.00 (–)13.5%1.00 (–)3.0%1.00 (–)
    Yes5.0%0.98 (0.87 to 1.10)1.9%0.88 (0.73 to 1.06)13.6%1.00 (0.93 to 1.07)2.7%0.86 (0.74 to 1.01)
  • *Exposures in first and after first trimester adjusted for each other, and in addition adjusted for other vitamins and cod liver oil in pregnancy, and for maternal age, maternal atopy, maternal smoking in pregnancy, maternal educational level, postnatal parental smoking, sex, parity, birth weight, season born and breast feeding. Estimates for age 6–18 months also adjusted for type of day care and supplement use at 6 months of age (cod liver oil and vitamins).

  • aRR, adjusted relative risks; LRTI, lower respiratory tract infection.