Perinatal data according to diagnostic categories in infants referred with raised TSH on neonatal screening during periods 1 and 2
| Definite CH | Probable CH | Diagnosis uncertain | Transient raised TSH | |||||
|---|---|---|---|---|---|---|---|---|
| Period 1 | Period 2 | Period 1 | Period 2 | Period 1 | Period 2 | Period 1 | Period 2 | |
| Period 1, 1979 to 1993; Period 2, 1994 to 2003. | ||||||||
| One patient in period 1 (0.3%) and 10 patients in period 2 (4%) in whom no category could be assigned have been excluded. | ||||||||
| *The term “sickness” at the time of sampling is defined as requiring neonatal intensive care ± respiratory support, intravenous fluids, intravenous antibiotic, and total parenteral nutrition. | ||||||||
| CH, congenital hypothyroidism; TSH, thyroid stimulating hormone. | ||||||||
| Number | 233 (67.2%) | 142 (56.8%) | 7 (2.02%) | 16 (6.4%) | 16 (4.6%) | 43 (17.2%) | 90 (25.9%) | 39 (15.6%) |
| (% of whole cohort) | ||||||||
| Female:male ratio | 2.1:1 | 1.8:1 | – | 7:1 | 1.67:1 | 1.2:1 | 0.91:1 | 1.7:1 |
| (158:75) | (92:50) | (7:0) | (14:2) | (10:6) | (24:20) | (43:47) | (24:14) | |
| Mean/median birth weight (kg) | 3.33/3.36 | 3.36/3.33 | 3.37/3.51 | 3.55/3.56 | 3.08/3.08 | 2.7/2.9 | 3.05/2.76 | 2.50/2.75 |
| Range | (1.28 to 5.9) | (1.0 to 4.9) | (3.05 to 4.4) | (2.7 to 4.5) | (1.23 to 4.22) | (0.69 to 4.25) | (0.78 to 4.32) | (0.74 to 4.57) |
| Gestation <37 weeks | 6.4% | 5.3% | 0.0% | 0.0% | 12.5% | 25.0% | 24.4% | 34.2% |
| Deaths (n (%)) | 5 (2.1%) | 1 (0.7%) | 0 (0%) | 0 (0%) | 6 (37.5%) | 5 (11.4%) | 4 (4.4%) | 0 (0%) |
| “Sick” infant* (% of total | 7.3% | 9.9% | 0.0% | 0.0% | 25.0% | 43.2% | 37.8% | 47.4% |
| in category) | ||||||||
| Jaundice (n (% of total | 125 (53.6%) | 71 (50.0%) | 4 (57.1%) | 5 (35.7%) | 4 (25.0%) | 11 (25.0%) | 27 (30.0%) | 5 (13.2%) |
| in category)) | ||||||||
| Poor feeding (n (% of total | 72 (30.9%) | 35 (24.6%) | 1 (14.3%) | 1 (6.25%) | 3 (18.75%) | 9 (20.4%) | 18 (20.0%) | 2 (5.3%) |
| in category)) | ||||||||