Table 2

 Case-control study (DIN) of hay fever and vaccinations

VaccineMonth(s) of lifeCounts (%)cases + controlsUnadjusted*Adjusted†Adjusted‡
OR95% CIp valueOR95% CIp valueOR95% CIp value
OR, odds ratio; 95% CI, 95% confidence interval.
*Unadjusted matched pairs analysis (2902 pairs for DTP and MMR; 2899 pairs for BCG).
†Adjusted for consultation frequency and restricted to pairs with non-ghost controls (2611 pairs for DTP and MMR; 2602 pairs for BCG).
‡Further adjusted for ACORN socioeconomic category (1845 pairs for DTP and MMR; 1843 pairs for BCG).
Tests for trend (non-ghost control pairs and adjusted for consultation frequency).
DTP: 0.90 (0.84, 0.96), p = 0.002; MMR: 0.95 (0.90, 0.99), p = 0.02.
5804 (100)
DTPDTP3 1st–4th716 (12.3)1.150.95 to 1.390.151.210.93 to 1.580.151.190.91 to 1.550.21
DTP3 5th2813 (48.5)111
DTP3 6th1055 (18.2)0.960.82 to 1.110.541.010.82 to 1.230.961.010.82 to 1.230.95
DTP3 7th–9th470 (8.1)0.880.71 to 1.090.230.990.74 to 1.310.920.990.74 to 1.310.92
DTP3 10th–12th207 (3.6)0.650.43 to 0.960.030.510.30 to 0.870.010.520.30 to 0.880.01
DTP3 13th+119 (2.1)0.710.49 to 1.050.090.640.38 to 1.100.100.670.39 to 1.140.14
Other DTP158 (2.7)0.940.63 to 1.400.751.040.60 to 1.810.901.020.59 to 1.780.94
Some pertussis203 (3.5)1.550.60 to 4.000.371.220.30 to 4.970.791.240.30 to 5.080.77
No pertussis63 (1.1)0.860.52 to 1.430.571.650.83 to 3.280.151.670.84 to 3.330.14
MMR1st–13th1128 (19.4)0.890.74 to 1.060.180.900.71 to 1.160.430.920.72 to 1.180.51
14th1769 (30.5)111
15th1192 (20.5)1.060.91 to 1.250.441.241.00 to 1.530.051.241.00 to 1.540.05
16th772 (13.3)0.870.71 to 1.060.160.960.73 to 1.390.790.970.73 to 1.280.81
17th335 (5.8)0.920.71 to 1.210.561.000.69 to 1.450.991.010.70 to 1.470.95
18th–24th379 (6.5)0.780.62 to 0.990.041.010.73 to 1.280.961.010.73 to 1.390.96
25th +119 (2.1)0.550.37 to 0.820.0030.540.31 to 0.950.030.570.32 to 0.990.05
No MMR110 (1.9)0.720.47 to 1.090.120.820.45 to 1.500.510.810.44 to 1.480.50
BCGBCG <2 y144 (2.5)1.290.89 to 1.880.181.310.86 to 2.000.211.250.79 to 1.960.34
No BCG/>2 y5654 (97.5)111