Outcome measures | Model | Studies included (reference no.) | Pooled point estimate | 95% CI | p value | Q test of heterogeneity p value (df) |
---|---|---|---|---|---|---|

OR of hospitalisation | Mantel-Haenszel fixed effect model | 11, 12, 14, 15 | 0.290 | 0.143 to 0.589 | 0.0006 | 0.13 (df = 3) |

OR of persistent PEFR <60% predicted | Mantel-Haenszel fixed effect model | 11, 12, 13 | 0.155 | 0.057 to 0.422 | 0.0003 | 0.97 (df = 2) |

Difference in percentage improvement of PEFR at study end | Hedges’s random effect model | 11, 13, 14 | 8.58 | 0.94 to 16.22 | 0.028 | <0.0001 (df = 2) |

Difference in clinical symptom score at study end | Hedges’s random effect model | 12, 13, 14, 15 | 1.33 | 0.31 to 2.36 | 0.011 | 0.0001 (df = 3) |