Table 2

 Pooled effect size estimates and tests of heterogeneity

Outcome measuresModelStudies included (reference no.)Pooled point estimate95% CIp valueQ test of heterogeneity p value (df)
OR of hospitalisationMantel-Haenszel fixed effect model11, 12, 14, 150.2900.143 to 0.5890.00060.13 (df = 3)
OR of persistent PEFR <60% predictedMantel-Haenszel fixed effect model11, 12, 130.1550.057 to 0.4220.00030.97 (df = 2)
Difference in percentage improvement of PEFR at study endHedges’s random effect model11, 13, 148.580.94 to 16.220.028<0.0001 (df = 2)
Difference in clinical symptom score at study endHedges’s random effect model12, 13, 14, 151.330.31 to 2.360.0110.0001 (df = 3)