Cushing’s syndrome |
Distinctive clues
|
Short history of obesity (months rather than years) |
| Rapid height growth |
| Very rapid weight gain |
| Virilisation |
| Lack of family history of obesity |
| Overlap with simple obesity or PCOS (non-distinctive clues) |
| Striae |
| Buffalo hump |
| Hypertension |
| Acne |
| Hirsutism |
| |
Prader-Willi syndrome |
Distinctive clues
|
Hyperphagia |
| Learning difficulties |
| Small feet and hands |
| Neonatal hypotonia |
|
Non-distinctive clues
|
| Massive obesity |
| Hypogonadism. Note that apparent hypogonadism is extremely common in obese boys due to burying of the penis in the perineal fat pad |
| |
Leptin deficiency |
Distinctive clues
|
Nil |
|
Non-distinctive clues
|
| Early onset of massive obesity |
| Consanguineous parentage |
| |
Melanocortin 4 receptor deficiency |
Distinctive signs
|
Nil |
|
Non-distinctive clues
|
| Early onset severe obesity |
| Hyperphagia |