Commonly used antiemetics and the receptors they block (adapted from Twycross and Back4)
| D2 | H1 | ACh | 5-HT2 | 5-HT3 | 5-HT4 | |
|---|---|---|---|---|---|---|
| Metoclopramide | ++ | 0 | 0 | 0 | (+) | ++ |
| Domperidone | ++ | 0 | 0 | 0 | 0 | 0 |
| Ondansetron | 0 | 0 | 0 | 0 | +++ | 0 |
| Cyclizine | 0 | ++ | ++ | 0 | 0 | 0 |
| Hyoscine | 0 | 0 | +++ | 0 | 0 | 0 |
| Haloperidol | +++ | 0 | 0 | 0 | 0 | 0 |
| Prochlorperazine | ++ | + | 0 | 0 | 0 | 0 |
| Chlorpromazine | ++ | ++ | + | 0 | 0 | ? |
| Levomepromazine | ++ | +++ | ++ | +++ | 0 | ? |