Response to treatment
| Once daily regime | Multi-dose regimes | ||
|---|---|---|---|
| Died (95% CI) | 21/155 14%(9% to 20%) | 18/142 13%(8% to 19%) | p = 0.99 |
| 1 hour peak gentamicin concentration <4 μg/ml (95% CI) | 7/136 5%(2% to 10%) | 35/123 28%(21% to 37%) | p<0.001 |
| Geometric mean 1 hour peak gentamicin concentration (±1 SD) (μg/ml) | 9.0(5.3, 15.4) | 4.7(2.5, 9.0) | p<0.001 |
| “72 hour” peak gentamicin concentration <4 μg/ml (95% CI) | 12/102 12%(6% to 20%) | 18/97 19%(11% to 28%) | p = 0.24 |
| Geometric mean “72 hour” peak gentamicin concentration (±1 SD) (μg/ml) | 6.2(2.8, 13.7) | 5.5(3.0, 9.8) | p = 0.19 |
| “96 hour” trough gentamicin concentration ⩾2 μg/ml in OD and MD groups (95% CI) | 5/89 6%(2% to 13%) | 21/86 24%(16% to 35%) | p = 0.001 |
| “96 hour” trough gentamicin concentration ⩾1 μg/ml in OD group and ⩾2 μg/ml MD group (95% CI) | 21/89 24%(15% to 34%) | 21/86 24%(16% to 35%) | p = 0.99 |
| Geometric mean “96 hour” trough gentamicin concentration (±1 SD) (μg/ml) | 0.6(0.3, 1.3) | 1.1(0.7, 2.3) | p<0.001 |
| Proportion with possible gentamicin nephrotoxicity (95% CI) | 1/89 1%(0% to 6%) | 2/85 2%(0% to 8%) | p = 0.6 |
| Mean fall in plasma creatinine (μmol/l) at “96 hours” (95% CI) | 18(11 to 25) | 11(5 to 17) | p = 0.13 |