Duration of treatment | p value (Wilcoxon) | ||||||
---|---|---|---|---|---|---|---|
Analyte | Baseline | 2 weeks | 2 months | >4 months | 2 weeks | 2 months | >4 months |
Data are expressed as median values (range) and number of subjects. All p values relate to comparisons with baseline values. | |||||||
Plasma calcium (mmol/l) | 2.26 | 2.30 | 2.31 | 2.37 | 0.64 | 0.23 | 0.13 |
(1.63–2.54) | (1.15–2.50) | (2.01–2.54) | (2.06–2.54) | ||||
26 | 15 | 15 | 9 | ||||
Phosphate (mmol/l) | 1.48 | 1.63 | 1.6 | 1.7 | 0.08 | 0.29 | 0.03 |
(0.89–2.40) | (1.13–2.24) | (1.04–2.38) | (1.38–2.01) | ||||
25 | 15 | 15 | 9 | ||||
PTH (pmol/l) | 5.3 | 2.9 | 3.8 | 1.7 | 0.28 | 0.03 | 0.03 |
(0.4–21.5) | (0.3–14.9) | (0.02–19) | (0.45–7.4) | ||||
26 | 15 | 15 | 8 | ||||
1,25D (pmol/l) | 473 | 407 | 400 | 281 | 0.04 | 0.88 | 0.04 |
(251–1057) | (283–820) | (113–1194) | (155–481) | ||||
24 | 14 | 14 | 9 | ||||
25D (nmol/l) | 36 | 37 | 47 | 44 | 0.08 | 0.21 | 0.05 |
(15–202) | (15–115) | (24–78) | (31–80) | ||||
26 | 15 | 15 | 7 | ||||
iPINP (μg/l) | 1102 | 1028 | 829 | 902 | 0.61 | 0.16 | 0.12 |
(402–1840) | (627–3355) | (60–2440) | (410–1254) | ||||
24 | 15 | 15 | 9 | ||||
PICP (μg/l) | 561 | 524 | 409 | 475 | 0.76 | 0.12 | 0.48 |
(171–1402) | (241–1275) | (155–1226) | (295–668) | ||||
25 | 15 | 15 | 9 | ||||
ICTP (μg/l) | 20 | 17 | 13 | 14 | 0.08 | 0.02 | 0.03 |
(7.2–103) | (9–71) | (8–67) | (11–24) | ||||
25 | 15 | 15 | 8 | ||||
ALP (IU/l) | 519 | 401 | 374 | 283 | 0.75 | 0.02 | 0.04 |
(178–1078) | (158–945) | (176–859) | (209–443) | ||||
26 | 15 | 15 | 9 | ||||
Osteocalcin (μg/l) | 14 | 17 | 22 | 32 | 0.61 | 0.39 | 0.9 |
(1–55) | (1–81) | (1–122) | (5–82) | ||||
26 | 15 | 15 | 9 |