Table 2

 Main areas which have been identified as potentially interfering with adherence29–31,34,35,40 and strategies to improve compliance/adherence27,30,32,38,39

Identified areasStrategies
Factors related to the adolescent
Cognitive factorsProvide information meeting the adolescent’s maturational stage
Perception of the diseaseTake into account underlying psychological factors
Emotional/psychological factorsTailor the treatment to the patient’s individuation process and stage
Patient educationCommunicate information in a straightforward way, trust the adolescent, do not hesitate to correct wrong ideas
Tailor the doses of the medication to the patient’s physiological status (puberty/growth)
Adapt the therapy to the adolescent’s lifestyles
Ask for proposals from the patient
Factors related to the teenager’s environment
Family functioningIf needed, suggest the support of siblings, peers
Peer influence
Factors related to the setting and communication
SettingIn each setting (paediatric or adult) keep the same professionals in charge of the same patients over time
Relationship with the healthcare team, communication styleAssess adherence regularly and in a non-threatening manner, check for side effects
Complexity of the therapeutic regimenSimplify the therapeutic regimen as much as possible, negotiate
Interference of the treatment with the adolescent’s needs and lifestyles