Children with CF and renal failure associated with antibiotic treatment
| Patient | Age | Weight (kg) | Other related problems | Pre-antibiotic plasma Cr (μmol/l) | Antibiotics used (mg/kg/day) | Gentamicin concentration* (mg/l) | Dose adjusted to (mg/kg/day) | Day first raised Cr noted | Biopsy findings | Peak Cr (μmol/l) | Treatment | Outcome at 3 months; Cr (μmol/l) |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| *Only out of range/inappropriate gentamicin levels tabulated. | ||||||||||||
| Cr, creatinine; ATN, acute tubular necrosis; NR, not recorded; PD, peritoneal dialysis; HD, haemodialysis; D, day. | ||||||||||||
| 1 | 9 y | 23 | Liver disease Constipation | 64 | Gentamicin 10 Cefuroxime 200 | 13.9 peak (D8) | Stopped | 9 | ATN | 862 (D16) | Conservative | 43 |
| 2 | 4 mth | 5.6 | Diarrhoea | 49 | Gentamicin 8.5 Ceftazidime 130 | 16.2 random (D18) | Course already completed | 17 | Not done | 494 (D19) | PD for 5 days | 55 |
| 3 | 7 y | 22 | Pseudo Bartter syndrome | NR | Gentamicin 12 Ceftazidime 150 | 10 peak 2.1 trough (D2) | 11 | 16 | ATN | 776 (D22) | HD for 4 days | 60 |