Key characteristics of 10 female patients treated for osteosarcoma, with cumulative doses of chemotherapeutic agents
| Patient | Age at diagnosis (y) | Duration of treatment (y) | Age at last follow up (y) | Follow up time (y) | Site of tumour | Type of surgery | MTX (g/m2) | CTX (g/m2) | IFO (g/m2) | VP-16 (g/m2) | CDDP (mg/m2) | ADM (mg/m2) | B (mg/m2) | D (mg/m2) | VCR (mg/m2) |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MTX, high dose methotrexate; CTX, cyclophosphamide; IFO, ifosfamide; VP-16, etoposide; CDDP, cisplatin; ADM, doxorubicin; B, bleomycin; D, dactinomycin; VCR, vincristine. | |||||||||||||||
| 1 | 6.4 | 1.2 | 21.2 | 13.6 | Dist. femur | Amputation | 61 | 5.8 | – | – | 740 | 450 | 140 | 5.8 | – |
| 2 | 10.7 | 1.5 | 16.2 | 4 | Dist. femur | Amputation | 56 | 3.6 | 17.0 | 1.2 | 330 | 300 | 90 | 3.6 | – |
| 3 | 11.4 | 1.0 | 17.9 | 5.5 | Prox. humerus | Limb salvage with fibulograft | 86 | – | 54.5 | 2.2 | 600 | 380 | – | – | – |
| 4 | 11.8 | 0.9 | 17.7 | 5 | Dist. femur | Limb salvage with endoprosthesis | 8 | 5.0 | – | – | 630 | 410 | 120 | 5.0 | – |
| 5 | 12.6 | 1.2 | 21.8 | 8 | Prox. femur | Hemipelvectomy | 18 | – | 63.5 | 3.5 | 710 | 350 | – | – | – |
| 6 | 13.1 | 1.2 | 19.2 | 4.9 | Dist. radius | Limb salvage with fibulograft | 126 | 4.8 | – | – | – | 390 | 90 | 6.6 | 6.3 |
| 7 | 14.8 | 1.3 | 17.6 | 1.5 | Prox. humerus | Limb salvage with fibulograft | 24 | 4.8 | 60.4 | 2.0 | 670 | 320 | 90 | 4.4 | – |
| 8 | 15.1 | 0.9 | 20.4 | 4.4 | Prox. tibia | Amputation | 55 | – | 35.1 | 2.0 | 350 | 220 | – | – | – |
| 9 | 15.2 | 0.9 | 18.9 | 2.8 | Pelvic girdle | Hemipelvectomy | 20 | – | 28.5 | 1.0 | 230 | 150 | – | – | – |
| 10 | 15.3 | 1.0 | 18.3 | 2 | Dist.radius | Limb salvage with fibulograft | 48 | 3.7 | 9.0 | 0.5 | 600 | 290 | 90 | 3.7 | – |