Parameter estimates for the final population model: Ka (h−1) = θ1, Cl/F (L/h) = (θ2*W+θ3*D)*(1−θ4*IDF), Vd/F (L) = (θ5*W+θ6*D)*(1+θ7*FS)
| Parameter | Estimate | SE (%)* | 95% CI |
|---|---|---|---|
| W, body weight; D, dose; θ, population specific pharmacokinetic parameter; IDF, ibuprofen dosage form (ibuprofen lysinate = 0/ibuprofen free acid = 1); FS, fasting status (fasting = 0/food = 1). | |||
| *Standard error of the estimate expressed as coefficient of variation (%). | |||
| †For a mean concentration of 38 mg/l. | |||
| θ1 | 6.66 | 31.47 | 2.52 to 10.80 |
| θ2 | 0.07 | 13.70 | 0.05 to 0.09 |
| θ3 | 0.08 | 20.84 | 0.05 to 0.11 |
| θ4 | 0.28 | 22.06 | 0.16 to 0.41 |
| θ5 | 0.10 | 18.98 | 0.06 to 0.16 |
| θ6 | 0.06 | 44.41 | 0.01 to 0.12 |
| θ7 | 0.37 | 45.34 | 2.52 to 10.80 |
| Interindividual variability: ω2Cl/F: 75% (CV); ω2Vd/F: 45% (CV) | |||
| Residual variability: σ2: ±6.74 mg/l (CV = 18%)† | |||