Base case | QALY Loss* | QALY Loss | £17673 |
Vaccine and epidemiological parameters
| | | |
Vaccine efficacy | | | |
Best case | QALY LOSS | QALY LOSS | £24755 |
Worst case | £11327 | £10181 | £8172 |
Vaccine coverage | | | |
50% infants, 50% children | QALY LOSS | QALY LOSS | £22841 |
95% infants, 90% children | QALY LOSS | QALY LOSS | £16837 |
Physician visits per case of varicella | | | |
Lower bound 90% CrI† | QALY LOSS | QALY LOSS | £19566 |
Upper bound 90% CrI† | QALY LOSS | QALY LOSS | £17717 |
Rate of hospitalisation and length of stay | | | |
Any ICD field | QALY LOSS | QALY LOSS | £18021 |
Summary outcomes
| | | |
Case fatality ratio of varicella | | | |
Lower bound 90% CrI† | QALY LOSS | QALY LOSS | £21126 |
Upper bound 90% CrI† | QALY LOSS | QALY LOSS | £11129 |
Case fatality ratio of zoster | | | |
Lower bound 90% CrI† | QALY LOSS | QALY LOSS | £17454 |
Upper bound 90% CrI† | QALY LOSS | QALY LOSS | £17801 |
QALY of varicella | | | |
Lower bound 90% CrI† | QALY LOSS | QALY LOSS | £46323 |
Upper bound 90% CrI† | QALY LOSS | QALY LOSS | £9582 |
QALY of zoster | | | |
Lower bound 90% CrI† | QALY LOSS | QALY LOSS | £12630 |
Upper bound 90% CrI† | QALY LOSS | QALY LOSS | QALY LOSS |
Costs
| | | |
Cost per vaccine course | | | |
−25% base case | QALY LOSS | QALY LOSS | £13081 |
+25% base case | QALY LOSS | QALY LOSS | £22266 |
Cost per consultation | | | |
−25% base case | QALY LOSS | QALY LOSS | £18680 |
+25% base case | QALY LOSS | QALY LOSS | £16667 |
Cost per inpatient day | | | |
−25% base case | QALY LOSS | QALY LOSS | £18004 |
+25% base case | QALY LOSS | QALY LOSS | £17306 |
Prior history of varicella | | | |
Sensitivity | | | |
90% | | QALY LOSS | £19047 |
99% | | QALY LOSS | £11048 |
Specificity | | | |
50% | | QALY LOSS | £28058 |
80% | | QALY LOSS | £14463 |
Model and methodological assumption
| | | |
Duration of immunity to zoster after exposure to VZV | | | |
7 years (lower bound 95% CI) | £9396 | £10449 | £7679 |
11 years (lower bound 75% CI) | QALY LOSS | QALY LOSS | £11421 |
41 years (upper bound 95% CI) | QALY LOSS | QALY LOSS | £31258 |
Discount rate | | | |
Benefits 6%, costs 6% | QALY LOSS | QALY LOSS | £74511 |
Benefits 3%, costs 6% | QALY LOSS | QALY LOSS | £11049 |
Benefits 0%, costs 6% | £6249 | £16933 | £1579 |
Benefits 0%, costs 3% | £10214 | £23289 | £2521 |
Benefits 0%, costs 0% | £19327 | £16511 | £5228 |
Time scale | | | |
30 years | QALY LOSS | QALY LOSS | £29988 |