Clinical characteristics, bronchial lavage, and lung function results from 36 CF subjects on 54 occasions, by infection group
| Infection (n=15) | No infection (n=39) | p value* | |
|---|---|---|---|
| *By GEE method to allow for repeated measures. | |||
| †Mean FEVt (ml) adjusted by regression analysis (GEE) for height, with 95% CI. | |||
| ‡Arithmetic (neutrophil %) and geometric (IL-8 and free neutrophil elastase) means and 95% CI. | |||
| Mean (SD) age (months) | 22.8 (6.7) | 15.9 (10.9) | 0.02 |
| Age range (months) | 12–36 | 1–37 | |
| Weight Z score, mean (SD) | −0.6 (1.1) | −0.2 (1.1) | 0.12 |
| Height Z score, mean (SD) | −0.3 (1.3) | −0.3 (1.1) | 0.74 |
| Daily cough in the week of testing, no. (%) | 7 (47%) | 13 (33%) | 0.32 |
| Taking oral antibiotics, no. (%) | 6 (40%) | 12 (31%) | 0.74 |
| Lung function† | |||
| FEV0.5 (ml) (n=54) | 203 (178 to 228) | 228 (209 to 246) | 0.06 |
| FEV0.75 (ml) (n=52) | 240 (209 to 272) | 266 (245 to 288) | 0.12 |
| FEV1 (ml) (n=49) | 272 (233 to 311) | 286 (261 to 311) | 0.50 |
| BL studies‡ | |||
| % neutrophils | 59 (47 to 70) | 28 (21 to 35) | <0.001 |
| IL-8 (pg/ml) | 641 (305 to 1350) | 253 (158 to 406) | 0.03 |
| Free neutrophil elastase (μg/ml) | 8.3 (5.3 to 13.1) | 5.6 (4.0 to 7.9) | 0.09 |