Table 1

Median lymphocyte numbers and immunoglobulin levels in 22q11.2 deletion patients with severe or recurrent infection

Patient (age)	Follow up (y)	Infection	CD3 (cells/μl)	CD4 (cells/μl)	CD8 (cells/μl)	CD19 (cells/μl)	IgM (g/l)	IgA (g/l)	IgG (g/l)	IgG subclass (g/l)	Sp Abs	Treatment
URTI, upper respiratory tract infection; LRTI, lower respiratory tract infection; IVIG, intravenous immunoglobulin.
*Recurrent infection which resolved with increasing age.
†Klebsiella oxytoca septicaemia.
‡Pseudomonas aeruginosa pneumonia.
*1 (6 y)	6	URTI, OM	1321	811	533	391	1.0	1.51	5.97	N	Low PPS	Nil
2 (7 y)	6	Pneumonia, URTI	1293	725	400	945	1.02	<0.07	13.3	High IgG1	N	Co-trimoxazole
3 (12 y)	4	Recurrent pneumonia	378	258	109	92	0.19	<0.07	2.2	Low IgG2	Low Tet, PPS	IVIG
4 (9 y)	8	OM, otorrhoea	—	—	—	—	0.68	2.31	16.8	N	N	Nil
5 (12 y)	7	Pneumonia, URTI, OM	560	295	274	306	0.28	0.57	7.85	N	N	Co-trimoxazole
6 (22 y)	10	URTI	505	243	297	156	0.66	1.1	11.4	N	Low PPS	Co-trimoxazole
7 (4 y)	2	URTI, otorrhoea	2163	1260	808	1147	0.33	0.39	5.7	N	Low PPS	Co-trimoxazole
8 (12 y)	1	OM, mastoiditis	643	355	244	313	0.6	0.58	13.0	N	N	Nil
9 (8 y)	8	URTI, endocarditis	1615	1052	567	550	0.46	1.54	7.95	N	Low Tet, PPS	Co-trimoxazole
10 (0.5 y)	0.5	Septicaemia^†	2725	1958	919	519	0.52	0.22	2.8	–	–	IVIG
11 (0.5 y)	0.5	Pneumonia‡	1048	816	265	367	0.53	0.19	4.02	N	–	Co-trimoxazole, IVIG
12 (5 y)	4	URTI	–	–	–	–	0.5	0.44	9.0	N	N	Co-trimoxazole
*13 (9 y)	7	URTI	1229	613	593	413	0.49	1.59	9.48	N	Low PPS	Nil
14 (7 y)	4	OM	3000	1248	1871	596	0.59	0.53	8.98	Low IgG2	Low PPS	Co-trimoxazole
15 (4 y)	4	LRTI	1542	971	550	762	0.49	0.27	5.25	N	N	Co-trimoxazole
16 (13 y)	6	LRTI Bronchiectasis	1264	1224	1010	581	0.86	<0.07	14.9	Low IgG2	Low Tet, PPS	Co-trimoxazole
*17 (17 y)	2	Pneumonia, sinusitis	778	439	310	233	1.2	1.87	8.61	N	N	Nil
18 (1 y)	1	Septicaemia	850	651	227	326	0.3	<0.07	5.0	N	N	Nil
19 (12 y)	2	Pneumonias	1224	629	437	297	0.77	1.7	10.6		N	Nil
20 (5 y)	5	URTI/LRTI	748	339	351	619	0.31	0.37	4.42	N	Low PPS	Co-trimoxazole
21 (6 y)	6	URTI, otorrhoea	799	382	309	765	0.89	0.73	7.4	N	Low PPS	Co-trimoxazole
*22 (4 y)	2	URTI, pneumonia	626	313	302	383	0.72	0.32	9.6	N	N	Co-trimoxazole
23 (9 y)	9	URTI	1582	831	582	985	0.54	1.83	12.1	N	N	Nil
24 (8 y)	2	URTI, pneumonia	821	397	316	558	0.37	0.93	7.15	Low IgG2	Low PPS	IVIG, co-trimoxazole
25 (5 y)	1	URTI	852	355	503	326	0.75	0.79	10.2	Low IgG1	N	Nil
26 (8 y)	1	Pneumonia, otorrhoea, mastoiditis	896	512	398	270	0.55	0.66	4.35	Low IgG1	N	Nil