Causes of treatment failure and comparative survival at 5 years in DS and non-DS patients
| Events | DS (n = 55) | Non-DS (n = 3596) | p value | |||||
|---|---|---|---|---|---|---|---|---|
| Number of events (%) | Outcome at 5 years, % (95% CI) | Number of events (%) | Outcome at 5 years, % (95% CI) | |||||
| Event free survival | 27 (49%) | 53% (39–66%) | 1401 (39%) | 63% (61–65%) | 0.1 | |||
| Survival | 21 (38%) | 73% (61–84%) | 799 (22%) | 82% (81–83%) | 0.007 | |||
| No remission | 1 (2%) | Not applicable | 50 (1%) | Not applicable | NS | |||
| Death in remission | 6 (11%) | 11% (3–20%) | 88 (2%) | 3% (2–3%) | <0.001 | |||
| Any relapse | 20 (37%) | 40% (26–54%) | 1263 (36%) | 35% (33–36%) | NS | |||
| Isolated CNS relapse | 2 (4%) | 4% (0–10%) | 226 (6%) | 7% (6–8%) | NS | |||
| Any CNS relapse | 8 (15%) | 18% (7–30%) | 434 (12%) | 13% (12–14%) | NS | |||
| Isolated BM relapse | 10 (19%) | 22% (9–35%) | 593 (17%) | 18% (17–19%) | NS | |||
| Any BM relapse | 18 (33%) | 37% (23–51%) | 900 (25%) | 26% (25–28%) | NS | |||
NS, p > 0.1.