Ion channel | Disorder | Inheritance | Gene | Chromosome |
Voltage gated | ||||
Sodium, β1 subunit | GEFS+ | Dominant | SCN1B | 19q |
Sodium, α1 subunit | GEFS+ | Dominant | SCN1A | 2q |
Potassium | BNFC | Dominant | KCNQ2 | 20q |
Potassium | BNFC | Dominant | KCNQ3 | 8q |
Potassium | EA1, EA1 and epilepsy, epilepsy and myokymia | Dominant | Kv1.1 | 12p |
Calcium | FHM, SCA6, EA2 | Dominant | CACNL1A4 | 19p |
Ligand gated | ||||
Neuronal nicotinic acetylcholine receptor, α4 subunit | ADNFLE | Dominant | CHRNA4 | 20q |
Neuronal nicotinic acetylcholine receptor, β2 subunit | ADNFLE | Dominant | CHRNB2 | 1p |
Glycine receptor | Hyperekplexia | Dominant, recessive | GLRA-1 | 5q |
GEFS+, generalised epilepsy with febrile seizures plus; BNFC, benign neonatal familial convulsions; EA1, episodic ataxia type 1; FHM, familial hemiplegic migraine; SCA6, spinocerebellar ataxia type 6; EA2, episodic ataxia type 2; ADNFLE, autosomal dominant nocturnal frontal lobe epilepsy.