Table 1

Phenotypes seen in male X-ALD patients

PhenotypeAge of onsetEstimated relative frequency
Adapted from Moser et al.1
Childhood cerebral3–10 years31–35%
Adolescent11–21 years4–7%
Adrenomyeloneuropathy19–37 years40–46%
Adult cerebralAdulthood2–5%
OlivopontocerebellarAdolescence or adulthood1–2%
Addison's onlyCommon before 7.5 yearsVaries with age; up to 50% in childhood
AsymptomaticBiochemical abnormality onlyDiminishes with age
Common <4 years
Very rare >40 years