Baseline characteristics of study patients by treatment groups (n=1459)
| Amoxicillin | Co-trimoxazole | |
|---|---|---|
| n=725 | n=734 | |
| n (%)* | n (%)* | |
| *Percentages in parenthesis unless specified; †Children's Hospital; ‡Federal Government Services Hospital; §assessed by either a prescription; presence of medicine bottle or the parent/caretaker knew the name of antibiotic medicine; ¶14 children ≥2 years old were still being breast fed in amoxicillin group and 12 in co-trimoxazole group. | ||
| Site enrolment | ||
| Gilgit (rural) | 42 (5.8) | 46 (6.3) |
| Gilgit (urban) | 84 (11.6) | 88 (12.0) |
| Islamabad CH† | 172 (23.7) | 165 (22.5) |
| Islamabad FGSH‡ | 142 (19.6) | 146 (19.9) |
| Karachi | 21 (2.9) | 19 (2.6) |
| Lahore | 45 (6.2) | 50 (6.8) |
| Multan | 24 (3.3) | 24 (3.3) |
| Rawalpindi | 195 (26.9) | 196 (26.7) |
| Age (median, range) | 12 (2–58) | 11 (2–59) |
| 2–11 months | 360 (49.7) | 372 (50.8) |
| 12–59 months | 365 (50.3) | 362 (49.2) |
| Sex (male) | 435 (60.0) | 448 (61.0) |
| Duration of illness in days (median, range) | 3.0 (1–29) | 3.0 (1–29) |
| History | ||
| Fever | 678 (93.5) | 681 (92.9) |
| Cough | 705 (97.2) | 719 (98.0) |
| Difficult breathing | 501 (69.1) | 506 (69.3) |
| Documented antibiotic use in past 7 days§ | 60 (8.3) | 64 (8.8) |
| Current breast feeding¶ | ||
| 2–11 months | 308 (42.5) | 309 (42.1) |
| 12–23 months | 129 (17.8) | 142 (19.3) |
| Examination | ||
| Respiratory rate (median, range) | ||
| 2–11 months | 59 (50–82) | 58 (50–84) |
| 12–59 months | 49 (40–79) | 50 (40–83) |
| Wheezing | ||
| 2–11 months | 47 (6.5) | 37 (5.0) |
| 12–59 months | 38 (5.2) | 37 (5.0) |
| Weight for age z score (median, range) | −1.11 (−3.95 to +3.07) | −0.94 (−3.62 to +3.51) |