Comparison of immunofluorescence, light microscopic, and electron microscopic findings between groups at the first and second biopsies
| First biopsy | Second biopsy | |||||
|---|---|---|---|---|---|---|
| Group S | Group N | p value | Group S | Group N | p value | |
| Results expressed as mean (SEM). | ||||||
| IF findings | ||||||
| IgG | 1.1 (1.1) | 0.9 (1.0) | NS | 1.1 (0.8) | 2.3 (0.5) | <0.05 |
| IgM | 0.7 (0.6) | 0.8 (0.7) | NS | 0.6 (0.4) | 1.1 (0.3) | <0.05 |
| IgA | 0.5 (0.7) | 0.4 (0.4) | NS | 0.1 (0.1) | 2.0 (0.8) | <0.05 |
| C1q | 0.9 (0.8) | 1.3 (0.9) | NS | 0.9 (0.5) | 1.1 (1.3) | NS |
| C3 | 2.6 (0.8) | 2.7 (0.5) | NS | 2.5 (0.4) | 3.0 (0.0) | NS |
| C4 | 0.3 (0.5) | 0.6 (0.4) | NS | 0.4 (0.3) | 0.8 (0.5) | NS |
| Fib | 1.5 (0.8) | 1.1 (0.6) | NS | 1.2 (0.6) | 2.3 (1.2) | NS |
| LM findings | ||||||
| Acute change | ||||||
| Thickening of capillary wall | 2.0 (0.8) | 2.4 (0.5) | NS | 1.3 (0.7) | 2.5 (0.6) | 0.07 |
| Mesangial proliferation | 2.2 (0.8) | 2.5 (0.5) | NS | 1.5 (0.9) | 2.1 (1.0) | NS |
| Open capillary lumens | 2.0 (0.8) | 2.4 (0.7) | NS | 1.3 (0.7) | 2.0 (1.0) | NS |
| Cellar crescent | 0.8 (0.8) | 1.4 (1.2) | 0.08 | 0.6 (0.5) | 0.8 (1.0) | NS |
| Interstitial inflammation | 1.2 (0.8) | 1.2 (0.9) | NS | 0.5 (0.7) | 1.8 (1.0) | NS |
| Chronic change | ||||||
| Fibrous crescent | 0.3 (0.4) | 0.8 (0.8) | <0.05 | 0.2 (0.3) | 2.0 (1.2) | <0.05 |
| Glomerular sclerosis | 0.2 (0.4) | 0.9 (0.8) | <0.01 | 0.5 (0.2) | 2.2 (1.0) | <0.05 |
| Tubular atrophy | 0.6 (0.7) | 1.3 (1.0) | <0.05 | 0.5 (0.5) | 1.8 (0.6) | 0.06 |
| Interstitial fibrosis | 0.5 (0.7) | 1.2 (1.0) | <0.05 | 0.4 (0.5) | 1.8 (1.0) | 0.07 |
| EM findings | ||||||
| MD | 2.6 (0.5) | 2.6 (0.5) | NS | 1.3 (0.8) | 2.0 (1.0) | NS |
| SEND | 2.3 (0.7) | 2.7 (0.6) | NS | 1.6 (0.80 | 2.5 (0.6) | 0.07 |
| SEPD | 1.4 (1.3) | 2.0 (1.2) | NS | 0.9 (1.1) | 2.3 (0.6) | 0.07 |