Bone marrow transplant characteristics
| Case number | ||||||||
|---|---|---|---|---|---|---|---|---|
| Characteristic | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 |
| Type | URD | URD | URD | URD | URD | HLA-id | URD | HLA-id |
| T cell depletion | CD34+ stem cell selection | C1M in vitro | CD34+ stem cell selection | CD34+ stem cell selection | C1G in vitro | Whole marrow | CD34+ stem cell selection | Whole marrow |
| HLA match (mismatch) | 10/10 | 10/10 | 9/10 (B,C) | 10/10 | 9/10 (DR) | 10/10 | 9/10 (C) | 10/10 |
| Nucleated cell dose/kg | 1×107 | 5.7×108 | 8.7×106 | 6.55×106 | 1.9×108 | 1.26×108 | 2.4×106 | 3.6×108 |
| CD34+ cell dose/kg | 9.1×106 | 1.7×106 | 7.5×106 | 5.8×106 | 5×106 | 7.26×106 | 1.8×106 | 3.9×106 |
| Neutrophil recovery | +21 | +95 | +22 | +24 | +38 | +19 | +24 | +13 |
| Platelet independence | +26 | +110 | +25 | +24 | – | – | – | +23 |
| Chimaerism (day + BMT) | Full, +104 | Partial lymphocyte, +120 | Full, +40 | Full, +26 | Partial, +70 | Full, +22 | Partial lymphocyte, +35 | – |
| GvHD | Nil | Nil | Nil | Nil | Grade 3 | Grade 4 | Nil | Grade 4 |
| Infection | Cytomegalovirus, parainfluenza 3 | Adenovirus 5, HHV6 | Trichophyton rubrum(nail) | Astrovirus, adenovirus 2 | Adenovirus 1 | Cryptosporidium, cytomegalovirus | Cryptosporidium | Cryptosporidium |
| Treatment | Foscarnet | Foscarnet, ribivarin | Itraconazole | – | Ganciclovir, ribivarin | Clarithromycin | Clarithromycin | Clarithromycin |
| Outcome (years post BMT) | A (+0.5) | A (+3.5) | A (+1.25) | A (+1.7) | D (+82); MSOF; disseminated adenovirus 1 | D (+34); liver failure; GvHD | D (+87); MSOF | D (+36); liver failure; post liver biopsy |
BMT, bone marrow transplantation; C1G, CAMPATH 1G; C1M, CAMPATH 1M; GvHD, graft versus host disease; MSOF, multisystem organ failure; URD, unrelated donor.