Facial angiofibromas or forehead plaque |
 Periungual fibromas |
Shagreen patch |
Retinal hamartoma |
Cortical hamartoma |
Subependymal nodule |
Giant cell astrocytoma |
Cardiac rhabdomyoma |
Renal angiomyolipoma or pulmonary lymphangiomyomatosis |
When two of these lesions are found in one individual, the diagnosis of TSC is beyond reasonable doubt. In most affected individuals it is possible to find evidence of two such lesions.